ArticleAge (Dordrecht, Netherlands)2014
Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiorespiratory and metabolic consequences of detraining in endurance athletes.Frontiers in physiology · 2023Pooled it
- High-intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional female soccer athletes.Experimental physiology · 2025Trial
- Greater Protein Intake Emphasizing Lean Beef Does Not Affect Resistance Training-Induced Adaptations in Skeletal Muscle and Tendon of Older Women: A Randomized Controlled Feeding Trial.The Journal of nutrition · 2024Trial
- Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.GeroScience · 2021Trial
- Muscles adaptation to aging and training: architectural changes - a randomised trial.BMC geriatrics · 2021Trial
- Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults.BMC geriatrics · 2019Trial
- Impact of controlled type 2 diabetes on muscle-tendon mechanics.Acta diabetologica · 2026Article
- Immunohistological detection of pentosidine in the epiglottis:A contribution to molecular age estimation.International journal of legal medicine · 2026Article
- Age-related changes in the quadriceps tendon: Collagen fibril diameter decreases with aging.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2025Article
- Leisure-time physical activity predicts levels of advanced glycation end-products in older women: A 15-year follow up from the Helsinki Birth Cohort Study.Geriatrics & gerontology international · 2025Article
- Basic Science Research in Frozen Shoulder: Current Updates.Indian journal of orthopaedics · 2025Article
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Subcutaneous advanced glycation end products, cardiovascular risk factors and vascular health during childhood development in a Swiss population.Frontiers in physiology · 2024Article
- Muscle-tendon unit design and tuning for power enhancement, power attenuation, and reduction of metabolic cost.Journal of biomechanics · 2023Review
- Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age.GeroScience · 2023Article
- Differences in the cross-sectional area along the ankle tendons with both age and sex.Journal of anatomy · 2023Article
- Collagen supplementation augments changes in patellar tendon properties in female soccer players.Frontiers in physiology · 2023Article
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Usefulness of Skin Autofluorescence as a Biomarker of Acute Oxidative Stress in Young Male Japanese Long-Distance Runners: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2022Article
- Role of Knee and Ankle Extensors' Muscle-Tendon Properties in Dynamic Balance Recovery from a Simulated Slip.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life-long regular endurance exercise is known to counteract the deterioration of cardiovascular and metabolic function and overall mortality. Yet it remains unknown if life-long regular endurance exercise can influence the connective tissue accumulation of advanced glycation endproducts (AGEs) that is associated with aging and lifestyle-related diseases. We therefore examined two groups of healthy elderly men: 15 master athletes (64 ± 4 years) who had been engaged in life-long endurance running and 12 old untrained (66 ± 4 years) together with two groups of healthy young men; ten young athletes matched for running distance (26 ± 4 years), and 12 young untrained (24 ± 3 years). AGE cross-links (pentosidine) of the patellar tendon were measured biochemically, and in the skin, it was assessed by a fluorometric method. In addition, we determined mechanical properties and microstructure of the patellar tendon. Life-long regular endurance runners (master athletes) had a 21 % lower AGE cross-link density compared to old untrained. Furthermore, both master athletes and young athletes displayed a thicker patellar tendon. These cross-sectional data suggest that life-long regular endurance running can partly counteract the aging process in connective tissue by reducing age-related accumulation of AGEs. This may not only benefit skin and tendon but also other long-lived protein tissues in the body. Furthermore, it appears that endurance running yields tendon tissue hypertrophy that may serve to lower the stress on the tendon and thereby reduce the risk of injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.