ArticleEnvironmental science and pollution research international2014
Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats.
Article in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Toxicological assessment of exposure to pharmaceutical effluents in rats for 28 days by repeated oral dose.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Assessment of reproductive, genotoxic, and cytotoxic effects of leachate-contaminated water in male mice.Heliyon · 2024Article
- Multi-taxon trends and the application of genotoxic biomarkers in the analysis of effluents from sewage treatment plant.Heliyon · 2023Review
- Polyphenols-Rich Fruit (Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100 % for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100 % concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p<0.05) for micronucleated cells from liver were noticed at 50 % concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.
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Registered trials
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