ArticleGenetics2014
Genome-wide patterns of differentiation among house mouse subspecies.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Evolution of Gene Expression Across Functional Regions of the Mouse Placenta.Genome biology and evolution · 2026Article
- Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.PLoS genetics · 2024Article
- Immunoglobulin genes, reproductive isolation and vertebrate speciation.Immunology and cell biology · 2022Article
- Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis.Genome biology and evolution · 2022Article
- Vicariance followed by secondary gene flow in a young gazelle species complex.Molecular ecology · 2021Article
- Further resolution of the house mouse (Mus musculus) phylogeny by integration over isolation-with-migration histories.BMC evolutionary biology · 2020Article
- Patterns of Genomic Differentiation in the Drosophila nasuta Species Complex.Molecular biology and evolution · 2020Article
- Wild-derived mice: from genetic diversity to variation in immune responses.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Recent admixture between species of the fungal pathogenEvolution letters · 2018Article
- Selection and environmental adaptation along a path to speciation in the Tibetan frogProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The genomic landscape at a late stage of stickleback speciation: High genomic divergence interspersed by small localized regions of introgression.PLoS genetics · 2018Article
- Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia.PLoS genetics · 2018Article
- Genomic islands of differentiation in two songbird species reveal candidate genes for hybrid female sterility.Molecular ecology · 2018Article
- Modularity Facilitates Flexible Tuning of Plastic and Evolutionary Gene Expression Responses during Early Divergence.Genome biology and evolution · 2018Article
- The genomic ancestry, landscape genetics and invasion history of introduced mice in New Zealand.Royal Society open science · 2018Article
- Variation in recombination frequency and distribution across eukaryotes: patterns and processes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- A genomic perspective on hybridization and speciation.Molecular ecology · 2016Review
- Gene regulation and speciation in house mice.Genome research · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
One approach to understanding the genetic basis of speciation is to scan the genomes of recently diverged taxa to identify highly differentiated regions. The house mouse, Mus musculus, provides a useful system for the study of speciation. Three subspecies (M. m. castaneus, M. m. domesticus, and M. m. musculus) diverged ∼350 KYA, are distributed parapatrically, show varying degrees of reproductive isolation in laboratory crosses, and hybridize in nature. We sequenced the testes transcriptomes of multiple wild-derived inbred lines from each subspecies to identify highly differentiated regions of the genome, to identify genes showing high expression divergence, and to compare patterns of differentiation among subspecies that have different demographic histories and exhibit different levels of reproductive isolation. Using a sliding-window approach, we found many genomic regions with high levels of sequence differentiation in each of the pairwise comparisons among subspecies. In all comparisons, the X chromosome was more highly differentiated than the autosomes. Sequence differentiation and expression divergence were greater in the M. m. domesticus-M. m. musculus comparison than in either pairwise comparison with M. m. castaneus, which is consistent with laboratory crosses that show the greatest reproductive isolation between M. m. domesticus and M. m. musculus. Coalescent simulations suggest that differences in estimates of effective population size can account for many of the observed patterns. However, there was an excess of highly differentiated regions relative to simulated distributions under a wide range of demographic scenarios. Overlap of some highly differentiated regions with previous results from QTL mapping and hybrid zone studies points to promising candidate regions for reproductive isolation.
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Registered trials
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