ArticleBMC urology2014
Comparison of the simplified International Index of Erectile Function (IIEF-5) in patients of erectile dysfunction with different pathophysiologies.
Article in BMC urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06100432 (Effect of Eurycoma Longifolia), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) on Sperm Parameters and Reproductive Hormones of Infertile Males in Yogyakarta, Indonesia
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.International urology and nephrology · 2017Pooled it
- Targeting Side Effects Associated with Androgen Deprivation Therapy Using Melatonin: A Randomized Trial on Hot Flashes and Sexual Health in Prostate Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2026Trial
- Sexual dysfunction in male patients with obesity: is it still being overlooked?Hormones (Athens, Greece) · 2025Article
- Patient-reported outcome measures in penile cancer: a narrative review.International journal of impotence research · 2025Review
- The methylation site cg06972019 regulates the succinylation-related gene ENO1 to inhibit the occurrence of erectile dysfunction.Hereditas · 2025Article
- Penile Erection Morphometry: The Need for a Novel Approach.The world journal of men's health · 2024Review
- Interaction of smoking and spicy habits modifies the risk of erectile dysfunction.Translational andrology and urology · 2024Article
- IcarifilJournal of clinical medicine · 2024Article
- Efficacy of acupuncture for psychogenic erectile dysfunction: a randomized, sham-controlled trial.Basic and clinical andrology · 2023Article
- Prevalence and associated factors of moderate to severe erectile dysfunction among adult men in Malaysia.Scientific reports · 2023Article
- Factors associated with anxiety and depression in patients with erectile dysfunction: a cross-sectional study.BMC psychology · 2023Article
- Prevalence of sexual dysfunction among the male populations who seeking medical care for infertility, pregnancy loss and preconception care: a cross-sectional study.Scientific reports · 2022Article
- Prevalence and associated factors of erectile dysfunction, psychological disorders, and sexual performance in primary vs. secondary infertility men.Reproductive biology and endocrinology : RB&E · 2021Article
- Do Urologists Really Recognize the Association Between Erectile Dysfunction and Cardiovascular Disease?Sexual medicine · 2020Article
- Perception of the association between erectile dysfunction and cardiovascular disease among Chinese physicians: an online survey.The Journal of international medical research · 2020Article
- Comparison of outcomes in malignant vs. non-malignant ischemic priapism: 12-year experience from a tertiary center.Turkish journal of urology · 2019Article
- Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study.International urology and nephrology · 2019Article
- Advantages and limitations of sleep-related erection and rigidity monitoring: a review.International journal of impotence research · 2018Review
- Hip Fracture in People with Erectile Dysfunction: A Nationwide Population-Based Cohort Study.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe simplified International Index of Erectile Function (IIEF-5) is a convenient, reliable and validated diagnostic tool for erectile dysfunction (ED). However, few studies focused on IIEF-5 in ED patients with different pathophysiological causes. ,We aim to compare the IIEF-5 score among ED patients with specific pathophysiologies in this study.
methodsThe IIEF-5 score of 3,327 ED patients (median age 39 years) was analyzed. The primary causes of ED were determined by comprehensive diagnostic procedures in the urology/andrology clinics in five training hospitals. Patients with uncertain pathophysiologic cause were excluded.
results176 patients were excluded, 3151 patients with ED history between 0.5 year and 20 years, were enrolled. The causes of ED was classified as psychogenic (59.2%), vasoculogenic (21.3%), neurogenic (4.1%), anatomical/structural (2.8%), hormonal (7.1%) or drug-induced (5.5%). A significant difference was detected in the median IIEF-5 score between psychogenic ED and organic ED (15 (IQR 13, 17) versus 12 (IQR 9.5, 14.5), P < 0.001). There was no significant difference of IIEF-5 scores among the organic groups (P = 0.073), or between arteriogenic and venogenic groups (13 (IQR 10.5, 15.5) versus 13 (IQR 11-15), P = 0.912 (adjusted α = 0.017)). However, the median IIEF-5 score of those with a mixed vascular cause was the lowest among vasculogenic patients (11 (IQR 8.5-13.5), scores for the three groups: P = 0.003.).
conclusionsThe IIEF-5 scores of men with psychological ED are higher than those with organic causes, but there is no difference among patients with different organic pathophysiologies. Our data indicate that IIEF-5 is not a definitive diagnostic tool to discriminate the pathophysiological causes of ED.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.