ArticleBMC genomics2014
Next generation sequencing gives an insight into the characteristics of highly selected breeds versus non-breed horses in the course of domestication.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Review: Genomic insights into the adaptive traits and stress resistance in modern horses.Stress biology · 2026Review
- Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds.BMC genomics · 2025Article
- Genome-Wide Detection of Copy Number Variations Associated with Miniature Features in Horses.Genes · 2023Article
- Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy.Journal of genetic mutation disorders · 2022Article
- Comparative Analysis for Genetic Characterization in Korean Native Jeju Horse.Animals : an open access journal from MDPI · 2021Article
- Selection in the Finnhorse, a native all-around horse breed.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Whole-Genome Signatures of Selection in Sport Horses Revealed Selection Footprints Related to Musculoskeletal System Development Processes.Animals : an open access journal from MDPI · 2019Article
- Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.Animal genetics · 2019Review
- Joint Estimates of Heterozygosity and Runs of Homozygosity for Modern and Ancient Samples.Genetics · 2019Article
- The horse Y chromosome as an informative marker for tracing sire lines.Scientific reports · 2019Article
- Genome data uncover four synergistic key regulators for extremely small body size in horses.BMC genomics · 2018Article
- Developing a 670k genotyping array to tag ~2M SNPs across 24 horse breeds.BMC genomics · 2017Article
- Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with Autoinflammatory Disease (SPAID).BMC genomics · 2017Article
- Screening of whole genome sequences identified high-impact variants for stallion fertility.BMC genomics · 2016Article
- Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses.BMC genomics · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDomestication has shaped the horse and lead to a group of many different types. Some have been under strong human selection while others developed in close relationship with nature. The aim of our study was to perform next generation sequencing of breed and non-breed horses to provide an insight into genetic influences on selective forces.
resultsWhole genome sequencing of five horses of four different populations revealed 10,193,421 single nucleotide polymorphisms (SNPs) and 1,361,948 insertion/deletion polymorphisms (indels). In comparison to horse variant databases and previous reports, we were able to identify 3,394,883 novel SNPs and 868,525 novel indels. We analyzed the distribution of individual variants and found significant enrichment of private mutations in coding regions of genes involved in primary metabolic processes, anatomical structures, morphogenesis and cellular components in non-breed horses and in contrast to that private mutations in genes affecting cell communication, lipid metabolic process, neurological system process, muscle contraction, ion transport, developmental processes of the nervous system and ectoderm in breed horses.
conclusionsOur next generation sequencing data constitute an important first step for the characterization of non-breed in comparison to breed horses and provide a large number of novel variants for future analyses. Functional annotations suggest specific variants that could play a role for the characterization of breed or non-breed horses.
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