Trial reportBMC nephrology2014
Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study.
Trial report in BMC nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00774137 (Phase IV Multi Center Validation Study of Novel Biomarkers of Acute Kidney Injury After Cardiac Surgery), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase IV Multi Center Validation Study of Novel Biomarkers of Acute Kidney Injury After Cardiac Surgery
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins.American journal of physiology. Renal physiology · 2026Article
- Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury.The Journal of clinical investigation · 2025Review
- Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes.Critical care (London, England) · 2024Article
- Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations.Journal of clinical medicine · 2024Review
- Associations between abrupt transition, dialysis-requiring AKI, and early mortality in ESKD among U.S. veterans.BMC nephrology · 2023Article
- Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases.Kidney international reports · 2023Article
- Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study.Annals of internal medicine · 2023Article
- Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study.Journal of the American Society of Nephrology : JASN · 2022Article
- A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death.Kidney international · 2021Article
- Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes.JAMA network open · 2020Article
- Exciting developments in the field of acute kidney injury.Nature reviews. Nephrology · 2020Review
- A simple real-time model for predicting acute kidney injury in hospitalized patients in the US: A descriptive modeling study.PLoS medicine · 2019Observational
- What endpoints should not be used for clinical studies of acute kidney injury?Intensive care medicine · 2018Article
- The Japanese Clinical Practice Guideline for acute kidney injury 2016.Journal of intensive care · 2018Article
- Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study.Biomarker research · 2018Article
- Expanding the Role for Kidney Biopsies in Acute Kidney Injury.Seminars in nephrology · 2018Review
- AKI Adjudication: Do We Need It.Nephron · 2017Review
- An update on the role of the inflammasomes in the pathogenesis of kidney diseases.Pediatric nephrology (Berlin, Germany) · 2016Review
- Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury.Clinical kidney journal · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAdjudication of patient outcomes is a common practice in medical research and clinical trials. However minimal data exists on the adjudication process in the setting of Acute Kidney Injury (AKI) as well as the ability to judge different etiologies (e.g. Acute Tubular Necrosis (ATN), Pre-renal Azotemia (PRA)).
methodsWe enrolled 475 consecutive patients undergoing cardiac surgery at four sites of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) study. Three expert nephrologists performed independent chart review, utilizing clinical variables and retrospective case report forms with pre intra and post-operative data, and then adjudicated all cases of AKI (n = 67). AKI was defined as a > 50% increase in serum creatinine for baseline (RIFLE Risk). We examined the patterns of AKI diagnoses made by the adjudication panel as well as association of these diagnoses with pre and postoperative kidney injury biomarkers.
resultsThere was poor agreement across the panel of reviewers with their adjudicated diagnoses being independent of each other (Fleiss' Kappa = 0.046). Based on the agreement of the two out of three reviewers, ATN was the adjudicated diagnosis in 41 cases (61%) while PRA occurred in 13 (19%). Neither serum creatinine or any other biomarker of AKI (urine or serum), was associated with an adjudicated diagnosis of ATN within the first 24 post-operative hours.
conclusionThe etiology of AKI after cardiac surgery is probably multi-factorial and pure forms of AKI etiologies, such as ATN and PRA may not exist. Biomarkers did not appear to correlate with the adjudicated etiology of AKI; however the lack of agreement among the adjudicators impacted these results.
trial registrationClinicaltrials.gov: NCT00774137.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.