ArticleJournal of biomedical optics2014
Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposure.American journal of physiology. Heart and circulatory physiology · 2021Article
- Optical Electrophysiology in the Developing Heart.Journal of cardiovascular development and disease · 2018Review
- Supplementation with the Methyl Donor Betaine Prevents Congenital Defects Induced by Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2017Article
- Volumetric optical mapping in early embryonic hearts using light-sheet microscopy.Biomedical optics express · 2016Article
- Cardiac neural crest ablation results in early endocardial cushion and hemodynamic flow abnormalities.American journal of physiology. Heart and circulatory physiology · 2016Article
- Optical coherence tomography for embryonic imaging: a review.Journal of biomedical optics · 2016Review
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm.Biomedical optics express · 2015Article
- Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function.Birth defects research. Part C, Embryo today : reviews · 2014Review
- Capturing structure and function in an embryonic heart with biophotonic tools.Frontiers in physiology · 2014Review
- Optical Coherence Tomography for Brain Imaging and Developmental Biology.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Optical mapping (OM) of cardiac electrical activity conventionally collects information from a three-dimensional (3-D) surface as a two-dimensional (2-D) projection map. When applied to measurements of the embryonic heart, this method ignores the substantial and complex curvature of the heart surface, resulting in significant errors when calculating conduction velocity, an important electrophysiological parameter. Optical coherence tomography (OCT) is capable of imaging the 3-D structure of the embryonic heart and accurately characterizing the surface topology. We demonstrate an integrated OCT/OM imaging system capable of simultaneous conduction mapping and 3-D structural imaging. From these multimodal data, we obtained 3-D activation maps and corrected conduction velocity maps of early embryonic quail hearts. 3-D correction eliminates underestimation bias in 2-D conduction velocity measurements, therefore enabling more accurate measurements with less experimental variability. The integrated system will also open the door to correlate the structure and electrophysiology, thereby improving our understanding of heart development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.