ArticleEcotoxicology (London, England)2014
Responses of biomarkers in wild freshwater mussels chronically exposed to complex contaminant mixtures.
Article in Ecotoxicology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Saxitoxin Group Toxins Accumulation Induces Antioxidant Responses in Tissues ofAntioxidants (Basel, Switzerland) · 2022Article
- Snails from heavy-metal polluted environments have reduced sensitivity to carbon dioxide-induced acidity.SpringerPlus · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcellular biochemical biomarkers are valuable early warning indicators of environmental contaminant effects. Thus, the present study evaluated several biomarkers and the relationships among them in wild freshwater mussels (Lasmigona costata) from a gradient of metal exposure and differential levels of other urban-related influences in the Grand River (ON, Canada). The biomarkers examined are related to metal exposure [gill ion and metal concentrations (Na, K, Ca, Mg, Cd, Cu, Ni, Pb and Zn)], oxidative status [reactive oxygen species (ROS), catalase (CAT), superoxide dismutase (SOD), antioxidant capacity (ACAP)], sulfhydryl (SH) metabolism [glutathione (GSH), protein sulfhydryl groups (SH protein), glutathione S-transferase (GST), glutathione reductase (GR)], and lipid peroxidation. Gill metal concentration increased proportionally to waterborne metal concentration and disturbances in osmotic and divalent cations (Ca and Mg) concentrations were observed. This suggests that the observed effects are associated with metal exposure, although simultaneous relationships with other contaminants are also possible. Oxidative status biomarkers (ROS, SOD, CAT and ACAP) were more sensitive to urban-influences than gill metal concentration. In contrast, biomarkers involving SH metabolism (GSH, SH protein, total SH, GR and GST) were more correlated with gill metal concentration. Oxidative damage occurred when both metal and urban-related influences were high. Mechanistically, the way of dealing with oxidative stress changed when mussels were exposed to high levels of contaminants. The reduction in ROS content, SOD and CAT activity, and ACAP accompanying the stimulation of detoxification metabolism via SH (GSH and SH protein contents, GST and GR activities) and their association with gill metal concentration are discussed.
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