ArticleEuropean journal of medical research2014
Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts.
Article in European journal of medical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Promoting Re-Epithelialization in Diabetic Foot Wounds Using Integrative Therapeutic Approaches.Bioengineering (Basel, Switzerland) · 2025Article
- A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures.Bioengineering (Basel, Switzerland) · 2022Article
- Article
- Evaluation of pulsed electromagnetic field protocols in implant osseointegration: in vivo and in vitro study.Clinical oral investigations · 2021Article
- Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials.Cell proliferation · 2021Review
- A2A adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields.PloS one · 2020Article
- Pulsed Electromagnetic Fields and Tissue Engineering of the Joints.Tissue engineering. Part B, Reviews · 2018Article
- Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes.International journal of molecular sciences · 2017Article
- Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis.Scientific reports · 2017Article
- Effects of the pulsed electromagnetic field PST® on human tendon stem cells: a controlled laboratory study.BMC complementary and alternative medicine · 2016Article
- Article
- Modulation of cell function by electric field: a high-resolution analysis.Journal of the Royal Society, Interface · 2015Article
- Design and fabrication of helmholtz coils to study the effects of pulsed electromagnetic fields on the healing process in periodontitis: preliminary animal results.Journal of biomedical physics & engineering · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be markedly enhanced. Here, we report the use of the Somagen™ device, which is certified for medical use according to European laws. It generates low-frequency pulsed electromagnetic fields that trigger effects of a nature that are yet to be determined.
methodsA 1.5-cm wide, linear scrape was introduced into patellar tendon fibroblast cultures (N = 5 donors). Treatment was carried out every second day. The regimen was applied three times in total with 30 minutes comprising pulsed electromagnetic field packages with two fundamental frequencies (10 minutes of 33 Hz, 20 minutes of 7.8 Hz). Control cells remained untreated. All samples were analyzed for gap closure time, proliferation and apoptosis one week after induction of the scrape wound.
resultsThe mean time for bridging the gap in the nontreated cells was 5.05 ± 0.33 days, and in treated cells, it took 3.35 ± 0.38 days (P <0.001). For cell cultures with scrape wounds, a mean value for BrdU incorporation of OD = 0.70 ± 0.16 was found. Whereas low-frequency pulsed electromagnetic fields treated samples showed OD = 1.58 ± 0.24 (P <0.001). However, the percentage of apoptotic cells did not differ between the two groups.
conclusionsOur data demonstrate that low-frequency pulsed electromagnetic fields emitted by the Somagen™ device influences the in vitro wound healing of patellar tendon fibroblasts and, therefore, possibly increases wound healing potential.
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