ArticleInsights into imaging2014
Pulmonary Langerhans cell histiocytosis: the many faces of presentation at initial CT scan.
Article in Insights into imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Mixed Erdheim-Chester disease with thoraco-abdominal involvement.Acta radiologica open · 2025Article
- From diagnostic biopsy to bullectomy: A case of progressive complications in pulmonary langerhans cell histiocytosis.Respiratory medicine case reports · 2025Article
- Differentiation of Minute Pulmonary Meningothelial-Like Nodules and Adenocarcinoma In situ with CT RadiomicsCurrent medical imaging · 2025Article
- Non-metastatic causes of multiple pulmonary nodules.Insights into imaging · 2024Article
- Impact of an expert-derived, quick hands-on tool on classifying pulmonary hypertension in chest computed tomography: a study on inexperienced readers using RAPID-CT-PH.La Radiologia medica · 2024Observational
- Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis.Journal of personalized medicine · 2024Review
- Recurrent pneumothoraces in a patient with pulmonary Langerhans cell histiocytosis accompanied with unexpected histological changes.Archive of clinical cases · 2024Article
- Airspace Enlargement with Fibrosis in a Young Heavy Smoker Mimicking Diffuse Cystic Lung Disease.Medicina (Kaunas, Lithuania) · 2022Article
- The Octopus Sign-A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis.Diagnostics (Basel, Switzerland) · 2022Article
- Recurrence of primary disease following lung transplantation.ERJ open research · 2022Review
- Clinical analysis for 15 patients with pulmonary Langerhans cell histiocytosis and literature review.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Review
- Limited Utility of Chemotherapy for Pulmonary Langerhans Cell Histiocytosis Due to Unclear Diagnostic Criteria.Cureus · 2022Article
- A unique presentation of Pulmonary Langerhans Cell Histiocytosis.Respiratory medicine case reports · 2022Article
- Pulmonary granulomatosis of genetic origin.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Early and Atypical Radiologic Presentations of Pulmonary Langerhans Cell Histiocytosis: A Report of Two Cases.Taehan Yongsang Uihakhoe chi · 2021Article
- Article
- Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation.Insights into imaging · 2019Review
- Article
- A missed case of pulmonary histiocytosis in a young lung donor.Journal of thoracic disease · 2018Article
- Cardiothoracic manifestations of primary histiocytoses.The British journal of radiology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial granulomatous disease that usually affects young adults who are smokers. Chest computed tomography (CT) allows a confident diagnosis of PLCH only in typical presentation, when nodules, cavitated nodules and cysts coexist and predominate in the upper and middle lungs.
methodsThis article includes a pictorial essay of typical and atypical presentations of PLCH at initial chest CT. Various appearances of PLCH are illustrated and possible differential diagnosis is discussed.
resultsPLCH can present with some aspecific features that may cause diagnosis of the initial disease to be overlooked or other pulmonary diseases to be suspected. In cases of nodule presentation alone, the main differential diagnosis should include lung metastasis, tuberculosis and other infections, sarcoidosis, silicosis and Wegener's disease. In cases of cysts alone, the most common diseases to be differentiated are centrilobular emphysema and lymphangiomyomatosis. Clinical symptoms are usually non-specific, although a history of cigarette smoking, coupled with the presence of typical or suggestive findings at imaging, is key to suspecting the disease. Atypical presentations require surgical biopsy for diagnosis.
conclusionsThe radiologist should be familiar with PLCH imaging features to correctly diagnose the disease or need for further investigation. TEACHING POINTS: • PLCH is a rare interstitial smoking-related disease that usually affects young adults. • The typical first CT shows a mix of nodules, cavitary nodules and cysts in the upper-middle lungs. • Atypical appearance, either cysts or nodules alone, mandates that other diagnoses be considered. • Lung cystic involvement correlates with lung function abnormalities and predicts functional decline. • Integration of the clinical history and imaging results is key to diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.