ArticlePhysical review letters2014
Repulsive DNA-DNA interactions accelerate viral DNA packaging in phage Phi29.
Article in Physical review letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Methods for Studying Motor-Driven Viral DNA Packaging in Bacteriophages phi29, Lambda, and T4 via Single DNA Molecule Manipulation and Rapid Solution Exchange.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Optical Tweezers to Study Viruses.Sub-cellular biochemistry · 2024Review
- Ion-dependent DNA configuration in bacteriophage capsids.Biophysical journal · 2021Article
- Determining Trap Compliances, Microsphere Size Variations, and Response Linearities in Single DNA Molecule Elasticity Measurements with Optical Tweezers.Frontiers in molecular biosciences · 2021Article
- Function of a viral genome packaging motor from bacteriophage T4 is insensitive to DNA sequence.Nucleic acids research · 2020Article
- Functional Dissection of a Viral DNA Packaging Machine's Walker B Motif.Journal of molecular biology · 2019Article
- Portal Protein: The Orchestrator of Capsid Assembly for the dsDNA Tailed Bacteriophages and Herpesviruses.Annual review of virology · 2019Review
- Evidence that a catalytic glutamate and an 'Arginine Toggle' act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor.Nucleic acids research · 2019Article
- Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor.Nature communications · 2018Article
- Influence of Microscopic Interactions on the Flexible Mechanical Properties of Viral DNA.Biophysical journal · 2018Article
- A Molecular View of the Dynamics of dsDNA Packing Inside Viral Capsids in the Presence of Ions.Biophysical journal · 2017Article
- Single DNA molecule jamming and history-dependent dynamics during motor-driven viral packaging.Nature physics · 2016Article
- Walker-A Motif Acts to Coordinate ATP Hydrolysis with Motor Output in Viral DNA Packaging.Journal of molecular biology · 2016Article
- Shapes of minimal-energy DNA ropes condensed in confinement.Scientific reports · 2016Article
- The structure and intermolecular forces of DNA condensates.Nucleic acids research · 2016Article
- Phi29 Connector-DNA Interactions Govern DNA Crunching and Rotation, Supporting the Check-Valve Model.Biophysical journal · 2016Article
- Continuous allosteric regulation of a viral packaging motor by a sensor that detects the density and conformation of packaged DNA.Biophysical journal · 2015Article
- Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor.Journal of molecular biology · 2014Article
- Continuity of states between the cholesteric → line hexatic transition and the condensation transition in DNA solutions.Scientific reports · 2014Article
- Screened DNA packs faster.Nature materials · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We use optical tweezers to study the effect of attractive versus repulsive DNA-DNA interactions on motor-driven viral packaging. Screening of repulsive interactions accelerates packaging, but induction of attractive interactions by spermidine(3+) causes heterogeneous dynamics. Acceleration is observed in a fraction of complexes, but most exhibit slowing and stalling, suggesting that attractive interactions promote nonequilibrium DNA conformations that impede the motor. Thus, repulsive interactions facilitate packaging despite increasing the energy of the theoretical optimum spooled DNA conformation.
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Registered trials
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