ArticleCell2014
Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
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Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
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44 citing papers in PubMed, 113 citations in OpenAlex.
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- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease.JCI insight · 2022Article
- Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface.International journal of environmental research and public health · 2021Review
- Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation.The Journal of clinical investigation · 2021Article
- TCR β chain-directed bispecific antibodies for the treatment of T cell cancers.Science translational medicine · 2021Article
- The Many Faces of CD4International journal of molecular sciences · 2020Review
- Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases.American journal of respiratory and critical care medicine · 2020Article
- Metals and molecular carcinogenesis.Carcinogenesis · 2020Review
- Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients.Respiratory research · 2020Article
- A role for TNF-α in alveolar macrophage damage-associated molecular pattern release.JCI insight · 2020Article
- Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.Science immunology · 2020Article
- Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease.Frontiers in immunology · 2020Review
- Understanding the Localization of Berylliosis: Interaction of BeChemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Mercury-induced inflammation and autoimmunity.Biochimica et biophysica acta. General subjects · 2019Review
- Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype.The Journal of biological chemistry · 2019Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Gina M ClaytonHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Yang WangDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Frances CrawfordHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Andrey NovikovDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Brian T WimberlyDepartment of Biochemistry and Molecular Genetics, Howard Hughes Medical Institute, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Program in Structural Biology and Biochemistry, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Jeffrey S KieftDepartment of Biochemistry and Molecular Genetics, Howard Hughes Medical Institute, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Program in Structural Biology and Biochemistry, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Michael T FaltaDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Natalie A BowermanDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Philippa MarrackHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Andrew P FontenotDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Shaodong DaiDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. Electronic address: dais@njhealth.org.
John W KapplerHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA; Program in Structural Biology and Biochemistry, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. Electronic address: kapplerj@njhealth.org.
Howard Hughes Medical Institute · USNational Jewish Health · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MLife Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4MT Cells in Beryllium Sensitization and DiseaseP01ES011810 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI NEWMAN, LEE S · 2002 to 2013
$14.0MCHARACTERISTICS OF T CELL RECEPTORSR01AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 1985 to 2022
$7.3MPATHOGENIC T CELLS IN CHRONIC BERYLLIUM DISEASER01HL062410 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 1998 to 2017
$5.7MColorado Clinical and Translational Sciences InstituteKL2TR001080 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$2.6MREGULATORY MECHANISMS IN THE IMMUNE SYSTEMR01AI017134 · NIAID · NATIONAL JEWISH HEALTH · PI KAPPLER, JOHN W · 1985 to 2006
$1.6MPatient-Oriented Research in Immunologic Lung Disease.K24HL102245 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 2010 to 2020
$1.4MColorado Clinical and Translational Sciences InstituteTL1TR001081 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$1.3MColorado Clinical and Translational Science Institute (KL2)KL2TR000156 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$521kRegulatory Mechanisms in the Immune SystemR56AI017134 · NIAID · NATIONAL JEWISH HEALTH · PI KAPPLER, JOHN W · 2007 to 2007
$321kColorado Clinical and Translational Science Institute (TL1)TL1TR000155 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$294kHoward Hughes Medical InstituteNCATS NIH HHS KL1TR000155NCATS NIH HHS KL2 TR000156NCATS NIH HHS KL2TR000156NCATS NIH HHS KL2 TR001080NCATS NIH HHS TL1 TR001081NCATS NIH HHS UL1 TR001082NHLBI NIH HHS HL62410NHLBI NIH HHS HL92997NHLBI NIH HHS K24 HL102245NHLBI NIH HHS R01 HL062410NHLBI NIH HHS R01 HL092997NIAID NIH HHS AI17134NIAID NIH HHS AI17785NIAID NIH HHS R01 AI017134NIAID NIH HHS R01 AI018785NIAID NIH HHS R56 AI017134NIEHS NIH HHS ES011810NIEHS NIH HHS P01 ES011810NIGMS NIH HHS P41 GM111244
Abstract
T-cell-mediated hypersensitivity to metal cations is common in humans. How the T cell antigen receptor (TCR) recognizes these cations bound to a major histocompatibility complex (MHC) protein and self-peptide is unknown. Individuals carrying the MHCII allele, HLA-DP2, are at risk for chronic beryllium disease (CBD), a debilitating inflammatory lung condition caused by the reaction of CD4 T cells to inhaled beryllium. Here, we show that the T cell ligand is created when a Be(2+) cation becomes buried in an HLA-DP2/peptide complex, where it is coordinated by both MHC and peptide acidic amino acids. Surprisingly, the TCR does not interact with the Be(2+) itself, but rather with surface changes induced by the firmly bound Be(2+) and an accompanying Na(+) cation. Thus, CBD, by creating a new antigen by indirectly modifying the structure of preexisting self MHC-peptide complex, lies on the border between allergic hypersensitivity and autoimmunity.
Indexed as
AutoimmunityBerylliosisBerylliumCD4-Positive T-LymphocytesCrystallography, X-RayHLA-DP beta-ChainsHumansHypersensitivityLungModels, MolecularReceptors, Antigen, T-CellSodiumBerylliumHLA-DP beta-ChainsHLA-DPw2 antigenReceptors, Antigen, T-CellSodium
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