Evidence map›Paper›PMID 24995981›Full record

ArticleCell2014

The histone variant H2A.W defines heterochromatin and promotes chromatin condensation in Arabidopsis.

Ramesh Yelagandula, Hume Stroud, Sarah Holec, Keda Zhou, Suhua Feng, Xuehua Zhong, Uma M Muthurajan, Xin Nie, Tomokazu Kawashima, Martin Groth and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 347 citations in OpenAlex.

  1. Review
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  10. Intermediate evolutionary state of motile sperm and pollen tubes in the extant gymnospermProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
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  14. Review
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  17. Histone variant H2A.W7 represses meiotic crossover formation inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025
    Review
  19. Article
  20. DDM1 Maintains Heterochromatin by Regulating Histone Variants.International journal of molecular sciences · 2025
    Review

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ramesh YelagandulaTemasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore.
Hume StroudDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sarah HolecTemasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore.
Keda ZhouDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Suhua FengDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xuehua ZhongDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Uma M MuthurajanDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Xin NieTemasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore.
Tomokazu KawashimaTemasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore.
Martin GrothDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Karolin LugerDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA; Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO 80523, USA.
Steven E JacobsenDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jacobsen@ucla.edu.
Frédéric BergerTemasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore. Electronic address: fred@tll.org.sg.
University of California, Los Angeles · USColorado State University · USTemasek Life Sciences Laboratory · SGNational University of Singapore · SG

Funding

Structure and Function of Nucleosome Assembly Protein 1R01GM067777 · NIGMS · UNIVERSITY OF COLORADO · PI LUGER, KAROLIN · 2003 to 2015
$3.7M
Actions of DRM3 on DRM2 mediated DNA methylationF32GM096483 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHONG, XUEHUA · 2011 to 2011
$53k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM096483NIGMS NIH HHS F32GM096483-01NIGMS NIH HHS GM067777NIGMS NIH HHS R01 GM067777
6 · The paper itself

Abstract

Histone variants play crucial roles in gene expression, genome integrity, and chromosome segregation. We report that the four H2A variants in Arabidopsis define different genomic features, contributing to overall genomic organization. The histone variant H2A.W marks heterochromatin specifically and acts in synergy with heterochromatic marks H3K9me2 and DNA methylation to maintain transposon silencing. In vitro, H2A.W enhances chromatin condensation by promoting fiber-to-fiber interactions via its conserved C-terminal motif. In vivo, H2A.W is required for heterochromatin condensation, demonstrating that H2A.W plays critical roles in heterochromatin organization. Similarities in conserved motifs between H2A.W and another H2A variant in metazoans suggest that plants and animals share common mechanisms for heterochromatin condensation.

Indexed as

Chromatin Assembly and DisassemblyAmino Acid SequenceArabidopsisArabidopsis ProteinsDNA MethylationDNA Transposable ElementsGenome-Wide Association StudyHeterochromatinHistonesMolecular Sequence DataSequence AlignmentArabidopsis ProteinsDNA Transposable ElementsHeterochromatinHistones

Identifiers

PMID24995981
PMCPMC4671829
OpenAlexW1983671446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.