ArticleAmerican journal of human genetics2014
Examining variation in recombination levels in the human female: a test of the production-line hypothesis.
Article in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Multicohort analysis of the maternal age effect on recombination.Nature communications · 2015Pooled it
- Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities.Annual review of genetics · 2025Review
- Follicular metabolic dysfunction, oocyte aneuploidy and ovarian aging: a review.Journal of ovarian research · 2025Review
- Re-Examination of PGT-A Detected Genetic Pathology in Compartments of Human Blastocysts: A Series of 23 Cases.Journal of clinical medicine · 2024Article
- Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.Nature communications · 2021Article
- Clinical Outcomes in High-Risk Pregnancies Due to Advanced Maternal Age.Journal of women's health (2002) · 2021Article
- Failure to recombine is a common feature of human oogenesis.American journal of human genetics · 2021Article
- Reduced retinoic acid synthesis accelerates prophase I and follicle activation.Reproduction (Cambridge, England) · 2020Article
- Crossover Interference, Crossover Maturation, and Human Aneuploidy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females.G3 (Bethesda, Md.) · 2016Article
- Interpreting the Dependence of Mutation Rates on Age and Time.PLoS biology · 2016Article
- Molecular insights into the aetiology of female reproductive ageing.Nature reviews. Endocrinology · 2015Review
- Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis.Biology of reproduction · 2015Article
- Oocyte development, meiosis and aneuploidy.Seminars in cell & developmental biology · 2015Review
- Meiosis and maternal aging: insights from aneuploid oocytes and trisomy births.Cold Spring Harbor perspectives in biology · 2015Review
- Escape from crossover interference increases with maternal age.Nature communications · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The most important risk factor for human aneuploidy is increasing maternal age, but the basis of this association remains unknown. Indeed, one of the earliest models of the maternal-age effect--the "production-line model" proposed by Henderson and Edwards in 1968--remains one of the most-cited explanations. The model has two key components: (1) that the first oocytes to enter meiosis are the first ovulated and (2) that the first to enter meiosis have more recombination events (crossovers) than those that enter meiosis later in fetal life. Studies in rodents have demonstrated that the first oocytes to enter meiosis are indeed the first to be ovulated, but the association between the timing of meiotic entry and recombination levels has not been tested. We recently initiated molecular cytogenetic studies of second-trimester human fetal ovaries, allowing us to directly examine the number and distribution of crossover-associated proteins in prophase-stage oocytes. Our observations on over 8,000 oocytes from 191 ovarian samples demonstrate extraordinary variation in recombination within and among individuals but provide no evidence of a difference in recombination levels between oocytes entering meiosis early in fetal life and those entering late in fetal life. Thus, our data provide a direct test of the second tenet of the production-line model and suggest that it does not provide a plausible explanation for the human maternal-age effect, meaning that-45 years after its introduction-we can finally conclude that the production-line model is not the basis for the maternal-age effect on trisomy.
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Registered trials
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