ArticleJournal of labelled compounds & radiopharmaceuticals2014
Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.
Article in Journal of labelled compounds & radiopharmaceuticals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).International journal of oncology · 2025Review
- Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Review
- Hydrogenative-PHIP polarized metabolites for biological studies.Magma (New York, N.Y.) · 2021Review
- High fieldPhysical chemistry chemical physics : PCCP · 2021Article
- Metabolic and Molecular Imaging with Hyperpolarised Tracers.Molecular imaging and biology · 2018Review
- Effects of Deuteration ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
- Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018Review
- Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-ACS omega · 2018Article
- Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques.Chemistry, an Asian journal · 2018Review
- In vivo 13C-MRI using SAMBADENA.PloS one · 2018Article
- A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Aqueous, Heterogeneous Parahydrogen-InducedThe journal of physical chemistry. C, Nanomaterials and interfaces · 2017Article
- Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging.Nature communications · 2017Article
- Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents.Analytical chemistry · 2016Article
- Efficient Synthesis of Molecular Precursors for Para-Hydrogen-Induced Polarization of Ethyl Acetate-1-(13) C and Beyond.Angewandte Chemie (International ed. in English) · 2016Article
- Toward Production of PureRSC advances · 2016Article
- Article
- NMR hyperpolarization techniques for biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Propane-The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- High-resolution low-field molecular magnetic resonance imaging of hyperpolarized liquids.Analytical chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Here, we present a new approach for the delivery of a metabolic contrast agent for in vivo molecular imaging. The use of a phosphate-protecting group that facilitates parahydrogen-induced polarization of 1-(13)C-phospholactate potentially enables the in vivo administration of a hydrogenated hyperpolarized adduct. When injected, nonhyperpolarized 1-(13)C-phospholactate is retained in the vasculature during its metabolic conversion to 1-(13)C-lactate by blood phosphatases as demonstrated here using a mucin 1 mouse model of breast cancer and ex vivo high-resolution (13)C NMR. This multisecond process is a suitable mechanism for the delivery of relatively short-lived (13)C and potentially (15)N hyperpolarized contrast agents using -OH phosphorylated small molecules, which is demonstrated here for the first time as an example of 1-(13)C-phospholactate. Through this approach, DL-1-(13)C-lactate is taken up by tissues and organs including the liver, kidneys, brain, heart, and tumors according to a timescale amenable to hyperpolarized magnetic resonance imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.