ArticleGenome biology2014
Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition.
Article in Genome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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The trial behind it
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Who cites it
150 citing papers in PubMed, 394 citations in OpenAlex.
- Impact of Macrolide Resistance on Azithromycin for Prevention of Rehospitalization or Death Among Children Discharged From Hospitals in Western Kenya.The Journal of infectious diseases · 2025Trial
- Water, sanitation, handwashing, and nutritional interventions can reduce child antibiotic use: evidence from Bangladesh and Kenya.Nature communications · 2025Trial
- Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease.The Journal of infectious diseases · 2024Trial
- Longitudinal Analysis of the Intestinal Microbiota among a Cohort of Children in Rural and Urban Areas of Pakistan.Nutrients · 2023Trial
- Comparison of sampling methods in assessing the microbiome from patients with ulcerative colitis.BMC gastroenterology · 2021Trial
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- Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh.EBioMedicine · 2016Trial
- Longitudinal Analysis of the Intestinal Microbiota in Persistently Stunted Young Children in South India.PloS one · 2016Trial
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- Stool microbial composition is associated with recent and future diarrhea and fever events in breastfed Danish infants.mSystems · 2026Observational
- Screening and dynamic change study of microbial and metabolite markers for calf diarrhea based on multi-omics and machine learning.mSystems · 2026Article
- Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response.Molecular psychiatry · 2026Review
- Segmented filamentous bacteria are worldwide human gut commensals.Nature communications · 2026Article
- Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling.Journal of advanced research · 2026Article
- Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid-AHR-NRF2 pathway activation.Journal of animal science and biotechnology · 2025Article
- Diversity and Functional Predictions of Gut Microbiota in Vietnamese Children Aged 6-24 Months with Persistent Diarrhea of Unknown Etiology.Pathogens (Basel, Switzerland) · 2025Article
- Metagenomic identification of disease-causingMicrobial genomics · 2025Article
- A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance.PLoS biology · 2025Article
- Fecal microbiome profiling of children withMicrobiology spectrum · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 11 institutions in 6 countries.
Funding
Abstract
backgroundDiarrheal diseases continue to contribute significantly to morbidity and mortality in infants and young children in developing countries. There is an urgent need to better understand the contributions of novel, potentially uncultured, diarrheal pathogens to severe diarrheal disease, as well as distortions in normal gut microbiota composition that might facilitate severe disease.
resultsWe use high throughput 16S rRNA gene sequencing to compare fecal microbiota composition in children under five years of age who have been diagnosed with moderate to severe diarrhea (MSD) with the microbiota from diarrhea-free controls. Our study includes 992 children from four low-income countries in West and East Africa, and Southeast Asia. Known pathogens, as well as bacteria currently not considered as important diarrhea-causing pathogens, are positively associated with MSD, and these include Escherichia/Shigella, and Granulicatella species, and Streptococcus mitis/pneumoniae groups. In both cases and controls, there tend to be distinct negative correlations between facultative anaerobic lineages and obligate anaerobic lineages. Overall genus-level microbiota composition exhibit a shift in controls from low to high levels of Prevotella and in MSD cases from high to low levels of Escherichia/Shigella in younger versus older children; however, there was significant variation among many genera by both site and age.
conclusionsOur findings expand the current understanding of microbiota-associated diarrhea pathogenicity in young children from developing countries. Our findings are necessarily based on correlative analyses and must be further validated through epidemiological and molecular techniques.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.