Evidence map›Paper›PMID 24995282›Full record

SynthesisBioMed research international2014

The relationship between interleukin-18 polymorphisms and allergic disease: a meta-analysis.

Daye Cheng, Yiwen Hao, Wenling Zhou, Yiran Ma

Open access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Effects ofFrontiers in genetics · 2022
    Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis.International journal of molecular sciences · 2016
    Review
  15. The Immunologic Mechanisms of Eosinophilic Esophagitis.Current allergy and asthma reports · 2016
    Review
  16. IL-18 and Cutaneous Inflammatory Diseases.International journal of molecular sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daye ChengDepartment of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.
Yiwen HaoDepartment of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.
Wenling ZhouDepartment of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.
Yiran MaDepartment of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have suggested that IL-18 -607C/A and -137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive. Therefore, we performed a meta-analysis to clarify whether IL-18 -607C/A and -137G/C polymorphisms were associated with the risk of allergic disease. A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis. In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 -607C/A or -137G/C polymorphism and the risk of allergic disease (all P > 0.05). However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 -607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 -137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison. In the stratified analysis by source of control, IL-18-607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 -137G/C only significantly decreased risk was found in the hospital-based subgroup. Our meta-analysis suggests that IL-18 -607C/A and -137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.

Indexed as

AsthmaDermatitisGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypersensitivityInterleukin-18Polymorphism, Single NucleotideRisk FactorsInterleukin-18

Identifiers

PMID24995282
PMCPMC4066680
OpenAlexW2168186583

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.