ArticleJournal of clinical and diagnostic research : JCDR2014
A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea.
Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Interventions for pityriasis rosea.The Cochrane database of systematic reviews · 2019Pooled it
- Effectiveness of acyclovir in the treatment of pityriasis rosea. A systematic review and meta-analysis.Anais brasileiros de dermatologiaPooled it
- Beyond the Herald Patch: Exploring the Complex Landscape of Pityriasis Rosea.American journal of clinical dermatology · 2025Review
- Comparative Efficacy of Different Pharmacological Treatments for Pityriasis Rosea: A Network Meta-Analysis.Journal of clinical medicine · 2024Review
- A Case of Persistent Pityriasis Rosea Successfully Treated by a Short Course of Therapy with Abrocitinib.Clinical, cosmetic and investigational dermatology · 2024Article
- From the Cochrane Library: Interventions for Pityriasis Rosea.JMIR dermatology · 2023Article
- Efficacy and Safety of Indigo Naturalis in Combination with Narrow-Band Ultraviolet B for Treatment of Pityriasis Rosea: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Clinical variants of pityriasis rosea.World journal of clinical cases · 2017Review
- Pityriasis Rosea: An Update on Etiopathogenesis and Management of Difficult Aspects.Indian journal of dermatologyReview
- Occult Hepatitis B Virus Infections (Often with Human Herpesvirus 7 Co-Infection) Detected inIndian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPityriasis rosea is an acute self-limiting skin disorder of unknown aetiology. Recently human herpes virus 6 and 7 has been hypothesized to be the cause of pityriasis rosea.
objectiveTo determine the efficacy of acyclovir, an anti-viral drug, in the treatment of pityriasis rosea. MATERIALS AND
methodsA randomized, double-blind, placebo-controlled study of efficacy of oral acyclovir in the treatment of pityriasis rosea was conducted on 73 patients. Thirty eight randomly selected patients were started on oral acyclovir. Thirty-five patients were prescribed placebo. The patients as well as the chief investigator were unaware of the therapeutic group to which patients belonged (acyclovir or placebo). Patients in both the groups were evaluated clinically after 7 and 14 days following the first visit and the data were analysed.
resultsFollow up data of 60 patients was available and these were included in the statistical analysis. 53.33% and 86.66% of the patients belonging to the acyclovir group showed complete resolution on the 7(th) day and 14(th) day respectively following the first visit compared to 10% and 33.33% of patients from the placebo group. The findings were statistically significant.
conclusionThe study showed that high dose acyclovir is effective in the treatment of pityriasis rosea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.