ArticleJournal of clinical and diagnostic research : JCDR2014
Molecular Characterization of Carbapenem Resistant Isolates of Acinetobacter baumannii in An Intensive Care Unit of A Tertiary Care Centre at Central India.
Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Detection of carbapenem resistance and its attributable genes in Acinetobacter baumannii isolated from cardiac patients at a referral cardiac hospital of Kathmandu.BMC microbiology · 2026Article
- Diversity of resistant determinants, virulence factors, and mobile genetic elements inFrontiers in cellular and infection microbiology · 2022Article
- Distribution of carbapenemase genes in clinical isolates ofThe Indian journal of medical research · 2020Article
- Multidrug-ResistantInfection and drug resistance · 2020Article
- Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes.Microbiome · 2019Article
- Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.The Indian journal of medical research · 2019Review
- High Proportions of Multidrug-Resistant Acinetobacter spp. Isolates in a District in Western India: A Four-Year Antibiotic Susceptibility Study of Clinical Isolates.International journal of environmental research and public health · 2018Article
- Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia.Clinical microbiology reviews · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo detect genes encoding carbapenem resistance in Acinetobacter baumannii in an intensive care unit.
methodsA. baumannii isolates were recovered from various clinical specimens of hospitalized patients admitted to the Medical and Surgical intensive care units of a tertiary care centre in Pune. Bacterial identification was performed by routine conventional microbial culture and biochemical tests using standard recommended techniques. Antibiotic sensitivity test was performed by standard Kirby Bauer disc diffusion technique. PCR amplification and automated sequencing was carried out.
resultsA total of 155 /368 (42.11%) isolates A. baumannii were found to have reduced susceptibility to imipenem (diameter of zones of inhibition ≤13mm) by disc diffusion method. Among these 155 isolates tested 130 (83.87%) isolates showed MIC values for imipenem and meropenem ranging from16-64 mg/L as per CLSI breakpoints. Among these 155 isolates, Carbapenemase production was confirmed by Modified Hodge test for 93 (60%) isolates. Out of 155 isolates, DDST was positive for 89 (57.41%), CDST was positive for 73(47.09%) and MBL (IP/IPI) E-test was positive for 105 (67.74%). blaOXA-51 gene was detected in 47/105 (44.76%), blaOXA-23 gene in 55/105 (52.38%) and blaOXA-58 like gene in 15/105 (14.28%).
conclusionMBL production along with co- production of OXA enzymes are considered to be the important reason for resistance to imipenem in Acinetobacter in our health care settings. Hence, early detection of these drug resistant genes by molecular methods is essential in limiting the spread of infection due to these organisms.
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