Evidence map›Paper›PMID 24995124›Full record

ArticleChemical science2014

A dual emission fluorescent probe enables simultaneous detection of glutathione and cysteine/homocysteine.

Xiao-Feng Yang, Qian Huang, Yaogang Zhong, Zheng Li, Hua Li, Mark Lowry, Jorge O Escobedo, Robert M Strongin

Open access · greenAbstract read
In one paragraph

Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 338 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Review
  8. Article
  9. Fluorescent Probes for Live Cell Thiol Detection.Molecules (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. WSMikrochimica acta · 2020
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiao-Feng YangKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P.R. China.
Qian HuangKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P.R. China.
Yaogang ZhongCollege of Life Sciences, Northwest University, Xi'an 710069, P.R. China.
Zheng LiCollege of Life Sciences, Northwest University, Xi'an 710069, P.R. China.
Hua LiKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P.R. China.
Mark LowryDepartment of Chemistry, Portland State University, Portland, OR, 97201, USA.
Jorge O EscobedoDepartment of Chemistry, Portland State University, Portland, OR, 97201, USA.
Robert M StronginDepartment of Chemistry, Portland State University, Portland, OR, 97201, USA.
Northwest University · CNPortland State University · USMinistry of Education of the People's Republic of China · CN

Funding

Synthesis and Study of Novel Sensing AgentsR01EB002044 · NIBIB · PORTLAND STATE UNIVERSITY · PI STRONGIN, ROBERT M · 2003 to 2010
$1.6M
NIBIB NIH HHS R01 EB002044
6 · The paper itself

Abstract

Many studies have shown that glutathione (GSH) and cysteine (Cys) / homocysteine (Hcy) levels are interrelated in biological systems. To unravel the complicated biomedical mechanisms by which GSH and Cys/Hcy are involved in various disease states, probes that display distinct signals in response to GSH and Cys/Hcy are highly desirable. In this work, we report a rhodol thioester (

Identifiers

PMID24995124
PMCPMC4074921
OpenAlexW2167666266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.