ArticleInternational journal of clinical and experimental medicine2014
In vitro hemocompatibility evaluation of poly (4-hydroxybutyrate) scaffold.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 29 citations in OpenAlex.
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- Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material.Materials science & engineering. C, Materials for biological applications · 2021Article
- Analysis of resorbable mesh implants in short-term human muscular fascia cultures: a pilot study.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biosynthetic thermoplastic poly-4-hydroxybutyrate (P4HB) possesses favorable tensile strength and elongation performance and has been studied as a new implantable polymer material for medical uses. However, its hemocompatibility has not been tested to confirm its applicability to tissue engineering. In this study, a series of experiments was performed that included erythrocyte hemolysis tests, dynamic blood coagulation tests, platelet adhesion tests, effects on blood coagulation, Wright staining, and adsorption of erythrocytes, leukocytes, platelets, and plasma proteins. The results were compared with control tests on polyvinyl chloride (PVC), a biomaterial in current use, to evaluate the relative in vitro hemocompatibility of P4HB. The degree of hemolysis in the presence of P4HB was 1.9 ± 0.2%. The absorbance-time curve for blood clotting declined slowly and smoothly. There were no differences in the test values of Factor XII, activated partial thromboplastin time (APTT), or fibrin degradation products (FDPs) among whole blood samples exposed to P4HB or PVC and the blank control groups (P > .05). Adsorption of platelets and globulin was similar in samples exposed to P4HB and PVC (P > .05), but the adsorption of erythrocytes, leukocytes, and albumin to P4HB was higher (P < .05). In conclusion, P4HB compares favorably with PVC in terms of blood compatibility, except for a higher affinity for erythrocytes and leukocytes. The findings indicate that P4HB, an alternate scaffolding material with advantageous properties, is generally acceptable for bioengineering use.
Indexed as
Identifiers
24995078PMC4073739W98862532What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.