Evidence map›Paper›PMID 24995049›Full record

ArticleCognitive neurodynamics2012

Modeling effect of GABAergic current in a basal ganglia computational model.

Felix Njap, Jens Christian Claussen, Andreas Moser, Ulrich G Hofmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive neurodynamics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Sleep, neuroengineering and dynamics.Cognitive neurodynamics · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Felix NjapInstitute for Signal Processing, University of Lübeck, 23538 Lübeck, Germany ; Graduate School for Computing Medicine and Life Sciences, University of Lübeck, Lübeck, Germany.
Jens Christian ClaussenGraduate School for Computing Medicine and Life Sciences, University of Lübeck, Lübeck, Germany ; Institute for Neuro-and Bioinformatics, University of Lübeck, 23538 Lübeck, Germany.
Andreas MoserDepartment of Neurology, University of Lübeck, 23538 Lübeck, Germany.
Ulrich G HofmannInstitute for Signal Processing, University of Lübeck, 23538 Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders. In order to shed light on its mode of action a computational model of the basal ganglia network coupled the HFS as injection current into the cells of the subthalamic nucleus (STN). Its overall increased activity rendered a faithful transmission of sensorimotor input through thalamo-cortical relay cells possible. Our contribution uses this model by Rubin and Terman (J Comput Neurosci, 16, 211-223, 2004) as a starting point and integrates recent findings on the importance of the extracellular concentrations of the inhibiting neurotransmitter GABA. We are able to show in this computational study that besides electrical stimulation a high concentration of GABA and its resulting conductivity in STN cells is able to re-establish faithful thalamocortical relaying, which otherwise broke down in the simulated parkinsonian state.

Indexed as

Computational modelDeep brain stimulationParkinsonian conditionSynaptic conductancesγ-Aminobutyric acid

Identifiers

PMID24995049
PMCPMC4079849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.