ArticleClinical proteomics2014
Analysis of age and gender associated N-glycoproteome in human whole saliva.
Article in Clinical proteomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Short Peptide with Sequence of LAGAAHF, Identified from Edible Bird's Nest, Reduces Dermatitis Symptoms in Mice.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Sex-Specific Salivary Biochemical Composition in a Healthy Population.International journal of molecular sciences · 2026Article
- Investigation of the relationship between caries predisposition and salivary characteristics.European oral research · 2026Article
- Advanced N-glycoproteomics and proteomics approach revealed sexually dimorphic molecular signatures in primary mouse hepatocyte.Analytical and bioanalytical chemistry · 2025Article
- Understanding If Differences in Salivary Flow Rate and Total Protein Content Triggered by Biological Factors (Sex and Age) Affect Aroma Perception and the Hedonic and Emotional Response of Wine Consumers.Foods (Basel, Switzerland) · 2022Article
- Glycosylation and Aging.Advances in experimental medicine and biology · 2021Article
- Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.Clinical oral investigations · 2020Article
- Inhibition of Influenza A Virus by Human Infant Saliva.Viruses · 2019Article
- Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry.Trends in analytical chemistry : TRAC · 2019Article
- Clinically Relevant Post-Translational Modification Analyses-Maturing Workflows and Bioinformatics Tools.International journal of molecular sciences · 2018Review
- iTRAQ-based quantitative analysis of age-specific variations in salivary proteome of caries-susceptible individuals.Journal of translational medicine · 2018Article
- Article
- The Function of Fucosylation in Progression of Lung Cancer.Frontiers in oncology · 2018Review
- Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment.International journal of oral science · 2017Review
- Development of a Multiplexed Liquid Chromatography Multiple-Reaction-Monitoring Mass Spectrometry (LC-MRM/MS) Method for Evaluation of Salivary Proteins as Oral Cancer Biomarkers.Molecular & cellular proteomics : MCP · 2017Article
- Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation.Clinical proteomics · 2015Article
- Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?International journal of medical sciences · 2015Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlycoproteins comprise a large portion of the salivary proteome and have great potential for biomarker discovery and disease diagnosis. However, the rate of production and the concentration of whole saliva change with age, gender and physiological states of the human body. Therefore, a thorough understanding of the salivary glycoproteome of healthy individuals of different ages and genders is a prerequisite for saliva to have clinical utility.
methodsFormerly N-linked glycopeptides were isolated from the pooled whole saliva of six age and gender groups by hydrazide chemistry and hydrophilic affinity methods followed by mass spectrometry identification. Selected physiochemical characteristics of salivary glycoproteins were analyzed, and the salivary glycoproteomes of different age and gender groups were compared based on their glycoprotein components and gene ontology. RESULTS AND DISCUSSION: Among 85 N-glycoproteins identified in healthy human saliva, the majority were acidic proteins with low molecular weight. The numbers of salivary N-glycoproteins increased with age. Fifteen salivary glycoproteins were identified as potential age- or gender-associated glycoproteins, and many of them have functions related to innate immunity against microorganisms and oral cavity protection. Moreover, many salivary glycoproteins have been previously reported as disease related glycoproteins. This study reveals the important role of salivary glycoproteins in the maintenance of oral health and homeostasis and the great potential of saliva for biomarker discovery and disease diagnosis.
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