Evidence map›Paper›PMID 24994858›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2014

Mechanistic and regulatory aspects of intestinal iron absorption.

Sukru Gulec, Gregory J Anderson, James F Collins

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 2 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 2 syntheses or guidelines pooled it, 386 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Observational
  12. Review
  13. Review
  14. [Chronic iron overload induces diminished ovarian reserve in miceNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  15. Review
  16. Review
  17. Review
  18. A Combination of Inulin and Long-Chain Fructooligosaccharides EnhancesJournal of agricultural and food chemistry · 2026
    Article
  19. Article
  20. Article

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sukru GulecFood Science & Human Nutrition Department, University of Florida, Gainesville, Florida; and.
Gregory J AndersonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
James F CollinsFood Science & Human Nutrition Department, University of Florida, Gainesville, Florida; and jfcollins@ufl.edu.
University of Florida · USQIMR Berghofer Medical Research Institute · AU

Funding

Molecular Mechanisms of Intestinal Metal Ion Transport During Iron-DeficiencyR01DK074867 · NIDDK · UNIVERSITY OF FLORIDA · PI COLLINS, JAMES F., VIDYASAGAR, SADASIVAN · 2007 to 2022
$5.1M
NIDDK NIH HHS 1 R01 DK-074867NIDDK NIH HHS R01 DK074867
6 · The paper itself

Abstract

Iron is an essential trace mineral that plays a number of important physiological roles in humans, including oxygen transport, energy metabolism, and neurotransmitter synthesis. Iron absorption by the proximal small bowel is a critical checkpoint in the maintenance of whole-body iron levels since, unlike most other essential nutrients, no regulated excretory systems exist for iron in humans. Maintaining proper iron levels is critical to avoid the adverse physiological consequences of either low or high tissue iron concentrations, as commonly occurs in iron-deficiency anemia and hereditary hemochromatosis, respectively. Exquisite regulatory mechanisms have thus evolved to modulate how much iron is acquired from the diet. Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin. Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation. Mucosal regulation of iron transport also occurs during low-iron states, via transcriptional (by hypoxia-inducible factor 2α) and posttranscriptional (by the iron-sensing iron-regulatory protein/iron-responsive element system) mechanisms. Recent studies demonstrated that these regulatory loops function in tandem to control expression or activity of key modulators of iron homeostasis. In health, body iron levels are maintained at appropriate levels; however, in several inherited disorders and in other pathophysiological states, iron sensing is perturbed and intestinal iron absorption is dysregulated. The iron-related phenotypes of these diseases exemplify the necessity of precisely regulating iron absorption to meet body demands.

Indexed as

Anemia, Iron-DeficiencyAnimalsBiological AvailabilityCation Transport ProteinsCytochromes bDietEnterocytesFerric CompoundsFerroportinHemeHemochromatosisHepatocytesHepcidinsHomeostasisHumansIntestinal AbsorptionCation Transport ProteinsCytochromes bFerric CompoundsFerroportinHemeHepcidinsIronSolute Carrier Family 11, Member 2divalent metal-ion transporter 1duodenumferroportin 1hepcidinhephaestin

Identifiers

PMID24994858
PMCPMC4137115
OpenAlexW2126030177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.