ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.
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Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38citing papers in PubMed, 1 pooled it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.International journal of cancer · 2019Pooled it
- Genome-wide interaction analysis of folate for colorectal cancer risk.The American journal of clinical nutrition · 2023Article
- Assessments of dietary intake and polygenic risk score in associations with colorectal cancer risk: evidence from the UK Biobank.BMC cancer · 2023Article
- A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.Cancer research · 2023Article
- Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer.JAMA network open · 2022Article
- Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk.Journal of the National Cancer Institute · 2022Article
- Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk.EClinicalMedicine · 2022Article
- Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Article
- Epidemiology, Molecular Mechanisms, and Clinical Trials: an Update on Research on the Association Between Red Meat Consumption and Colorectal Cancer.Current nutrition reports · 2021Review
- Association of four genetic variants with colorectal cancer in Kazakhstan population.Oncotarget · 2021Article
- Impact of Gene-Environment Interactions on Cancer Development.International journal of environmental research and public health · 2020Review
- Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- A Systematic Analysis of Interactions between Environmental Risk Factors and Genetic Variation in Susceptibility to Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.Cancer medicine · 2020Article
- The independent and combined effects of selected risk factors and Arg399Gln XRCC1 polymorphism in the risk of colorectal cancer among an Iranian population.Medical journal of the Islamic Republic of Iran · 2020Article
- Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs.BMC cancer · 2019Article
- Observational
- Interaction between physical activity,Oncotarget · 2018Article
- Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
46 authors.
Elizabeth D KantorDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. ekantor@hsph.harvard.edu.
Carolyn M HutterDivision of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
Jessica MinnierPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), Heidelberg, Germany.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program, Oakland, California.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Christopher S CarlsonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
Graham CaseyDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
Mengmeng DuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
David DugganTranslational Genomics Research Institute, Phoenix, Arizona.
Charles S FuchsChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Edward L GiovannucciDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.
Jian GongPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York.
Brian E HendersonKeck School of Medicine, University of Southern California, Los Angeles, California.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
John L HopperMelbourne School of Population Health, The University of Melbourne, VIC, Australia.
Mark A JenkinsMelbourne School of Population Health, The University of Melbourne, VIC, Australia.
Shuo JiaoPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Mathieu LemireOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Jing MaChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
Heather M Ochs-BalcomDepartment of Social and Preventive Medicine, University at Buffalo, Buffalo, New York.
Bethann M PflugeisenPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. Centre for Public Health Research, Massey University, Wellington, New Zealand.
Anja RudolphDivision of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Daniela SeminaraDivision of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
Deanna L StellingPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fridtjof ThomasDepartment of Preventive Medicine, University of Tennessee Health Science Center, University of Tennessee, Memphis, Tennessee.
Mark ThornquistPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Cornelia M UlrichPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
Greg S WarnickPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Brent W ZankeClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5MTraining Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MCIHRIntramural NIH HHS Z01 CP010200NCI NIH HHS CA42182NCI NIH HHS CA-95-011NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA053996NCI NIH HHS P01 CA 055075NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA 087969NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA48998NCI NIH HHS R01 CA60987NCI NIH HHS R01 CA63464NCI NIH HHS R25 CA094880NCI NIH HHS R25CA94880NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA54281NCI NIH HHS T32 CA009001NCI NIH HHS T32CA009001NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS GEI U01 HG 004438NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CPHS HHS R01 137178WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
backgroundGenome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene-environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.
methodsData on 9,160 cases and 9,280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects meta-analysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.
resultsNone of the permutation-adjusted P values reached statistical significance.
conclusionsThe associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors. IMPACT: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.
Indexed as
Gene-Environment InteractionAdultAgedAged, 80 and overCase-Control StudiesColorectal NeoplasmsDietFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors
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