ArticleAmerican journal of hypertension2015
Plasma lactate and incident hypertension in the atherosclerosis risk in communities study.
Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Effect ofInternational journal of environmental research and public health · 2020Trial
- Hypertension Drives Protein Lactylation and Vascular Dysfunction in Skeletal Muscle.Hypertension (Dallas, Tex. : 1979) · 2026Article
- [Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?]Revista brasileira de ortopedia · 2025Article
- Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?Revista brasileira de ortopedia · 2025Article
- Effects of mobile application-based dietary recommendations on patients aged 50 and older with type 2 diabetes, obesity, and hypertension in Gwangju, South Korea: a pilot trial.Nutrition research and practice · 2025Article
- Association of tricarboxylic acid cycle related-metabolites with hypertension in older adults: a community-based cross-sectional study.Journal of human hypertension · 2025Article
- Ultra-Processed Food Consumption and Risk of Incident Hypertension in US Middle-Aged Adults.Journal of the American Heart Association · 2024Article
- Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension.Journal of translational medicine · 2024Article
- Fasting plasma lactate as a possible early clinical marker for metabolic disease risk.Diabetes & metabolic syndrome · 2024Observational
- Gut Microbiota Modulation by Selenium and Zinc Enrichment Postbiotic on Dysbiosis Associated with Hypertension.Current vascular pharmacology · 2024Article
- Assessing the causal association between sleep apnea and the human gut microbiome composition: A two-sample Mendelian randomization study.SAGE open medicine · 2024Article
- Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review.Antioxidants (Basel, Switzerland) · 2023Review
- Current understanding of the contribution of lactate to the cardiovascular system and its therapeutic relevance.Frontiers in endocrinology · 2023Article
- Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: a cross-sectional study.Journal of translational medicine · 2022Article
- Clarifying the Link Between the Blood Lactate Concentration and Cardiovascular Risk.International journal of sports medicine · 2022Article
- Serum Lactate as Serum Biomarker for Cardiopulmonary Parameters within the First 24 Hours after a Spontaneous Intracerebral Hemorrhage.Diagnostics (Basel, Switzerland) · 2022Article
- Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals.Journal of hypertension · 2022Article
- Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats.Nutrients · 2021Article
- The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?Physiological reports · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecent evidence suggests that insufficient oxidative capacity or mitochondrial dysfunction may play a causal role in the development of high blood pressure. However, this hypothesis has not been tested in the general population. We hypothesized that lactate, a measure of oxidative capacity, would be positively associated with incident hypertension even after accounting for traditional hypertension risk factors.
methodsPlasma lactate was measured in 5,554 participants from the Atherosclerosis Risk in Communities (ARIC) Study with no subclinical or diagnosed hypertension at baseline (1996-1998). Incident hypertension was defined by self-report or hypertension medication use. Analyses were performed with Cox proportional hazards models.
resultsThe mean age was 61.9 years, and the mean lactate was 0.8 mmol/L. During a median follow-up period of 11.9 years (range = 26.9 days to 13.4 years), there were 3,849 new cases of hypertension. The fourth quartile of lactate (compared with the first quartile) was associated with an elevated risk of hypertension (hazard ratio (HR) = 1.18; 95% confidence interval (CI) = 1.07-1.31) even after adjustment for traditional risk factors, including baseline systolic and diastolic blood pressure. This association was stronger when the population was restricted to participants with normal blood pressure (<120mm Hg/<80mm Hg; HR = 1.42; 95% CI = 1.23-1.63). In strata of sex, the association was strong in women vs. null in men (P interaction = 0.01).
conclusionsPlasma lactate is associated with incident hypertension in women, especially with a normal blood pressure (<120mm Hg/<80mm Hg). Future studies should elucidate the mechanisms underlying these observations.
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