Evidence map›Paper›PMID 24994538›Full record

GuidelineAnnals of hematology2014

Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia.

Edouard Cornet, Alain Delmer, Pierre Feugier, Francine Garnache-Ottou, David Ghez, Véronique Leblond, Vincent Levy, Frédéric Maloisel, Daniel Re, Jean-Marc Zini and 2 more

Open access · hybridAbstract readPractice Guideline
In one paragraph

Guideline in Annals of hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Patients with relapsed/refractory hairy-cell leukemia.Cancer reports (Hoboken, N.J.) · 2022
    Article
  7. Advances in the Treatment of Hairy Cell Leukemia Variant.Current treatment options in oncology · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Biology and Treatment of Hairy Cell Leukemia.Current treatment options in oncology · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Long-term follow-up after purine analogue therapy in hairy cell leukaemia.Best practice & research. Clinical haematology · 2015
    Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 2 countries.

Edouard CornetHaematology Laboratory, Caen University Hospital, 14033, Caen Cedex, France.
Alain Delmer
Pierre Feugier
Francine Garnache-Ottou
David Ghez
Véronique Leblond
Vincent Levy
Frédéric Maloisel
Daniel Re
Jean-Marc Zini
Xavier Troussard
French Society of Haematology
Centre Hospitalier Universitaire de Caen Normandie · FRCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Sainte-Anne · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Reims · FRCentre Procédés, Energies Renouvelables et Systèmes Energétiques · FRHôpital Avicenne · FRInstitut Gustave Roussy · FRSaint Louis University Hospital · USSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hairy cell leukaemia (HCL) is a rare haematological malignancy, with approximately 175 new incident cases in France. Diagnosis is based on a careful examination of the blood smear and immunophenotyping of the tumour cells, with a panel of four markers being used specifically to screen for hairy cells (CD11c, CD25, CD103 and CD123). In 2011, the V600E mutation of the BRAF gene in exon 15 was identified in HCL; being present in HCL, it is absent in the variant form of HCL (HCL-v) and in splenic red pulp lymphoma (SRPL), two entities related to HCL. The management of patients with HCL has changed in recent years. A poorer response to purine nucleoside analogues (PNAs) is observed in patients with more marked leukocytosis, bulky splenomegaly, an unmutated immunoglobulin variable heavy chain (IgVH) gene profile, use of VH4-34 or with TP53 mutations. We present the recommendations of a group of 11 experts belonging to a number of French hospitals. This group met in November 2013 to examine the criteria for managing patients with HCL. The ideas and proposals of the group are based on a critical analysis of the recommendations already published in the literature and on an analysis of the practices of clinical haematology departments with experience in managing these patients. The first-line treatment uses purine analogues: cladribine or pentostatin. The role of BRAF inhibitors, whether or not combined with MEK inhibitors, is discussed. The panel of French experts proposed recommendations to manage patients with HCL, which can be used in a daily practice.

Indexed as

Antibodies, Monoclonal, Murine-DerivedAntigens, CDAntigens, NeoplasmAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorB-LymphocytesDiagnosis, DifferentialExonsFemaleGene Rearrangement, B-Lymphocyte, Heavy ChainHumansImmunophenotypingInterferon-alphaLeukemia, Hairy CellLymphoma, Non-HodgkinAntibodies, Monoclonal, Murine-DerivedAntigens, CDAntigens, NeoplasmAntimetabolites, AntineoplasticBiomarkers, TumorBRAF protein, humanInterferon-alphaNeoplasm ProteinsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafRituximab

Identifiers

PMID24994538
PMCPMC4221655
OpenAlexW2081139525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.