ArticleClinical and experimental nephrology2015
Case series of thromboembolic complications in childhood nephrotic syndrome: Hacettepe experience.
Article in Clinical and experimental nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Incidence of thromboembolism in children with primary nephrotic syndrome: a systematic review and metaanalysis.BMC nephrology · 2023Pooled it
- Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Urokinase prophylactic anticoagulation in children with nephrotic syndrome: a multicenter retrospective cohort study.BMC nephrology · 2024Article
- Mechanical Thrombectomy for Refractory Cerebral Venous Sinus Thrombosis in a Child with Nephrotic Syndrome : A Case Report.Journal of Korean Neurosurgical Society · 2023Article
- Complications Related to Childhood Idiopathic Nephrotic Syndrome, Its Treatment and the Associated Risks in Patients.Cureus · 2023Article
- Mesenteric Arterial Thrombosis Revealing Relapse of Nephrotic Syndrome in Young Women.International medical case reports journal · 2023Article
- Venous Thromboembolism in Kidney Diseases and Genetic Predisposition.Kidney diseases (Basel, Switzerland) · 2022Review
- Postoperative Intracardiac Thrombus in a Child with Nephrotic Syndrome.International medical case reports journal · 2022Article
- Spectrum of thrombotic complications and their outcomes in Chinese children with primary nephrotic syndrome.Italian journal of pediatrics · 2020Article
- Splenic Infarction as Starting Symptom in Minimal Change Nephropathy.Chinese medical journal · 2017Article
- The non-immunosuppressive management of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2016Review
- Vitamin K antagonists in children with central venous catheter on chronic haemodialysis: a pilot study.Pediatric nephrology (Berlin, Germany) · 2016Article
- Thromboembolic complications in children with primary nephrotic syndrome: A Tunisian series.La Tunisie medicaleArticle
- Cerebral Venous Sinus Thrombosis in a Child with Idiopathic Nephrotic Syndrome: a case report.Jornal brasileiro de nefrologiaArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to describe the incidence and contributory risk factors for thromboembolic complications in children with nephrotic syndrome (NS) and thrombosis.
methodsAmong 188 children with the diagnosis of NS (80 girls; mean age: 12.6 ± 5.4 years) followed up in our hospital for the last 5 years, 17 (9.0 %) children (16 boys) identified as having thromboembolic complications. All 17 children with NS and thrombosis were screened for laboratory risk factors for thrombosis. The diagnosis was confirmed by cranial magnetic resonance imaging, doppler ultrasonography, and echocardiography.
resultsAmong 17 children with thrombosis, 14 (82.3 %) were found to have focal segmental glomerulosclerosis (FSGS) as underlying pathology by renal biopsy. The mean age of the thrombotic children was 4.5 ± 3.2 years at the diagnosis of NS and that was 7.1 ± 4.9 years at the time of thrombosis. The mean time from NS diagnosis to the first thrombosis development was 2.6 ± 2.3 years. Thrombosis occurred during the first year of NS in 9/17 (52.9 %) children. Most of the children (88.2 %) had venous thrombosis. Among the screened risk factors, high factor VIII level (64.7 %) was the leading factor followed by decreased antithrombin III level (29.4 %). Furthermore, 4 children had central venous catheters and 2 had infection as clinical risk factors for thrombosis.
conclusionIn this case series, subtype of FSGS, active disease state of NS, central venous catheters, and some inherited and acquired thrombotic risk factors have been identified as contributory factors for the development of thrombosis in children with NS.
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