ArticleDevelopment (Cambridge, England)2014
Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 80 citations in OpenAlex.
- Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.International journal of molecular sciences · 2026Review
- Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste bud cell subtypes via KIT inhibition.Development (Cambridge, England) · 2026Article
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors.Nature communications · 2026Article
- Obesity-induced taste bud loss in mice is only partially remediated long after return to a healthy weight.International journal of obesity (2005) · 2026Article
- Tamoxifen triggers a transcriptional switch from proliferation to differentiation in the circumvallate taste epithelium in mice.Scientific reports · 2025Article
- Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages.Nature communications · 2025Article
- Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025Article
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.Development (Cambridge, England) · 2023Article
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates.International journal of molecular sciences · 2023Review
- Single-cell transcriptomics uncovers the differentiation of a subset of murine esophageal progenitors into taste buds in vivo.Science advances · 2023Article
- High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro.Development (Cambridge, England) · 2023Article
- Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The sense of taste: Development, regeneration, and dysfunction.WIREs mechanisms of disease · 2022Review
- Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity.Cellular and molecular life sciences : CMLS · 2022Article
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
- Immortalization and Characterization of Rat Lingual Keratinocytes in a High-Calcium and Feeder-Free Culture System Using ROCK Inhibitor Y-27632.International journal of molecular sciences · 2021Article
- Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.eLife · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Taste buds are assemblies of elongated epithelial cells, which are innervated by gustatory nerves that transmit taste information to the brain stem. Taste cells are continuously renewed throughout life via proliferation of epithelial progenitors, but the molecular regulation of this process remains unknown. During embryogenesis, sonic hedgehog (SHH) negatively regulates taste bud patterning, such that inhibition of SHH causes the formation of more and larger taste bud primordia, including in regions of the tongue normally devoid of taste buds. Here, using a Cre-lox system to drive constitutive expression of SHH, we identify the effects of SHH on the lingual epithelium of adult mice. We show that misexpression of SHH transforms lingual epithelial cell fate, such that daughter cells of lingual epithelial progenitors form cell type-replete, onion-shaped taste buds, rather than non-taste, pseudostratified epithelium. These SHH-induced ectopic taste buds are found in regions of the adult tongue previously thought incapable of generating taste organs. The ectopic buds are composed of all taste cell types, including support cells and detectors of sweet, bitter, umami, salt and sour, and recapitulate the molecular differentiation process of endogenous taste buds. In contrast to the well-established nerve dependence of endogenous taste buds, however, ectopic taste buds form independently of both gustatory and somatosensory innervation. As innervation is required for SHH expression by endogenous taste buds, our data suggest that SHH can replace the need for innervation to drive the entire program of taste bud differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.