ArticleBMJ (Clinical research ed.)1989
Concentrations of high density lipoprotein cholesterol, triglycerides, and total cholesterol in ischaemic heart disease.
Article in BMJ (Clinical research ed.), 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?BMJ (Clinical research ed.) · 1994Pooled it
- Randomised controlled trial in northern England of the effect of a person knowing their own serum cholesterol concentration.Journal of epidemiology and community health · 1994Trial
- Topical timolol and serum lipoproteins.The British journal of ophthalmology · 1990Trial
- Effects of evening primrose oil in rheumatoid arthritis.Annals of the rheumatic diseases · 1989Trial
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- Association of Opioid Prescription with Major Adverse Cardiovascular Events: Nationwide Cohort Study.Journal of clinical medicine · 2025Article
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- Lower serum triglyceride level is a risk factor for in-hospital and late major adverse events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention- a cohort study.BMC cardiovascular disorders · 2014Article
- The role of triglycerides in cardiovascular risk.Current cardiology reports · 2008Review
- Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events.Circulation · 2008Article
- Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study.Vascular health and risk management · 2007Review
- Cardiovascular disease: different strategies for primary and secondary prevention?Heart (British Cardiac Society) · 2004Review
- Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects.Indian journal of clinical biochemistry : IJCB · 2002Article
- High apolipoprotein AI concentrations are associated with lower mortality and myocardial infarction five years after coronary artery bypass graft surgery.Heart (British Cardiac Society) · 1999Article
- Impact of dyslipidaemia. Lessons from clinical trials.PharmacoEconomics · 1998Review
- Serum urate and the risk of major coronary heart disease events.Heart (British Cardiac Society) · 1997Article
- Triglyceride concentration and coronary heart disease.BMJ (Clinical research ed.) · 1995Article
- Asymptomatic hyperglycaemia and major ischaemic heart disease events in Britain.Journal of epidemiology and community health · 1994Article
- Triglyceride concentration and coronary heart disease.BMJ (Clinical research ed.) · 1994Article
- Serum lipids and coronary heart disease in British elderly.Postgraduate medical journal · 1993Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the roles of serum concentrations of total cholesterol, high density lipoprotein cholesterol, and triglycerides in predicting major ischaemic heart disease.
designMen recruited for the British regional heart study followed up for a mean of 7.5 years.
settingGeneral practices in 24 British towns. PATIENTS: 7735 Middle aged men. END POINT: Predictive value of serum concentrations of lipids. MEASUREMENTS AND MAIN
resultsAt initial screening serum concentrations of total cholesterol, high density lipoprotein cholesterol, and triglycerides were determined from non-fasting blood samples. Altogether 443 major ischaemic heart disease events (fatal and non-fatal) occurred during the study. Men in the highest fifth of the distribution of total cholesterol concentration (greater than or equal to 7.2 mmol/l) had 3.5 times the risk of ischaemic heart disease than did men in the lowest fifth (less than 5.5 mmol/l) after adjustment for high density lipoprotein cholesterol concentration and other risk factors. Men in the lowest fifth of high density lipoprotein cholesterol concentration (less than 0.93 mmol/l) had 2.0 times the risk of men in the highest fifth (greater than or equal to 1.33 mmol/l) after adjustment for total cholesterol concentration and other risk factors. Men in the highest fifth of triglyceride concentration (greater than or equal to 2.8 mmol/l) had only 1.3 times the risk of those in the lowest fifth (less than 1.08 mmol/l) after adjustment for total cholesterol concentration and other risk factors; additional adjustment for high density lipoprotein cholesterol concentration made the association with ischaemic heart disease disappear.
conclusionsSerum concentration of total cholesterol is the most important single blood lipid risk factor for ischaemic heart disease in men. High density lipoprotein cholesterol concentration is less important, and triglyceride concentrations do not have predictive importance once other risk factors have been taken into account.
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