Evidence map›Paper›PMID 24993907›Full record

ArticleThe European respiratory journal2014

Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis.

Joanna Smolonska, Gerard H Koppelman, Cisca Wijmenga, Judith M Vonk, Pieter Zanen, Marcel Bruinenberg, Ivan Curjuric, Medea Imboden, Gian-Andri Thun, Lude Franke and 25 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Polymorphisms in theJournal of thoracic disease · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Asthma-COPD overlap: current understanding and the utility of experimental models.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Advances in understanding COPD.F1000Research · 2016
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 17 institutions in 7 countries.

Joanna SmolonskaDept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands.
Gerard H KoppelmanGRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands Dept of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen, The Netherlands.
Cisca WijmengaDept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Judith M VonkDept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands.
Pieter ZanenDept of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
Marcel BruinenbergDept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ivan CurjuricDept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Medea ImbodenDept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Gian-Andri ThunDept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Lude FrankeDept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nicole M Probst-HenschDept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Peter NürnbergCologne Center for Genomics, University of Cologne, Cologne, Germany.
Roland A RiemersmaGRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Constant P van SchayckDept of General Practice, University of Maastricht, Maastricht, The Netherlands.
Daan W LothDept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Netherlands Healthcare Inspectorate, The Hague, The Netherlands.
Guy G BrusselleDept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Dept of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.
Bruno H StrickerDept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Netherlands Healthcare Inspectorate, The Hague, The Netherlands Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.
Albert HofmanDept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.
André G UitterlindenNetherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands Dept of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Lies LahousseDept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, USA.
Laura R LoehrUniversity of North Carolina, Chapel Hill, NC, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA Dept of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
R Graham BarrDept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kathleen M DonohueDept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Peter PareRespiratory Division, Dept of Medicine, University of British Columbia James Hogg Research Centre, St Paul's Hospital, Vancouver, BC, Canada.
Yohan BosséInstitut Universitaire De Cardiologie Et De Pneumologie De Québec, Dept of Molecular Medicine, Laval University, Québec, QC, Canada.
Ke HaoDept of Genetics and Genomics Sciences, Mount Sinai School of Medicine, New York, NY, USA.
Maarten van den BergeGRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Harry J M GroenDept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan-Willem J LammersDept of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
Willem MaliDept of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
H Marike BoezenDept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands.
Dirkje S PostmaGRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands d.s.postma@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLSwiss Tropical and Public Health Institute · CHUniversity Medical Center Utrecht · NLDutch Health Care Inspectorate · NLGhent University Hospital · BENetherlands Consortium for Healthy Ageing · NLOffice of Public Health Genomics · USColumbia College · CAIcahn School of Medicine at Mount Sinai · USMaastricht University · NLNational Institute of Environmental Health Sciences · USRoyal College of Physicians · GBUniversité Laval · CAUniversity of British Columbia · CAUniversity of Cologne · DEUniversity of North Carolina at Chapel Hill · US

Funding

Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
Intramural NIH HHS ZIA ES043012NHLBI NIH HHS R01 HL077612
6 · The paper itself

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors, performing genome-wide association studies for both asthma and COPD and combining the results in meta-analyses. Three loci showed potential involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) κβ pathway) and GNG5P5, respectively. Single nucleotide polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p=9.96×10(-9)). The second replication phase, in seven independent cohorts, provided no significant replication. Expression quantitative trait loci (eQTL) analysis in blood cells and lung tissue on the top 20 associated SNPs identified two SNPs in COMMD10 that influenced gene expression. Inflammatory processes differ in asthma and COPD and are mediated by NF-κβ, which could be driven by the same underlying genes, COMMD10 and DDX1. None of the SNPs reached genome-wide significance. Our eQTL studies support a functional role for two COMMD10 SNPs, since they influence gene expression in both blood cells and lung tissue. Our findings suggest that there is either no common genetic component in asthma and COPD or, alternatively, different environmental factors, e.g. lifestyle and occupation in different countries and continents, which may have obscured the genetic common contribution.

Indexed as

Genome-Wide Association StudyAdolescentAdultAgedAsthmaFemaleHumansMaleMiddle AgedNetherlandsPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveRisk FactorsYoung Adult

Identifiers

PMID24993907
PMCPMC4217133
OpenAlexW1974540015

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.