ArticleBMJ open2014
Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Early Life Added Sugars and Associated Appetite, Satiety, Growth and Adiposity in the First 2 Years of Life.Nutrients · 2026Article
- Transcriptome and Metabolome Analyses Uncover Genes and Pathways Linking Growth Trajectories to Cardiometabolic Risk Markers in Childhood.Current issues in molecular biology · 2026Article
- Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.American journal of epidemiology · 2019Article
- Association of accelerated body mass index gain with repeated measures of blood pressure in early childhood.International journal of obesity (2005) · 2019Article
- Childhood Fat and Lean Mass: Differing Relations to Vascular Structure and Function at Age 8 to 9 YearsArteriosclerosis, thrombosis, and vascular biology · 2018Article
- Postnatal height and adiposity gain, childhood blood pressure and prehypertension risk in an Asian birth cohort.International journal of obesity (2005) · 2017Article
- Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero.European journal of nutrition · 2017Article
- The Get-Up! study: adiposity and blood pressure in Australian toddlers.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTo assess whether changes in measures of fat distribution and body size during early life are associated with blood pressure at 36 months of age.
designAnalysis of data collected from a prospective cohort study.
settingCommunity-based investigation in Southampton, UK.
participants761 children with valid blood pressure measurements, born to women participating in the Southampton Women's Survey. PRIMARY AND SECONDARY OUTCOME MEASURES: Anthropometric measurements were collected at 0, 6, 12, 24 and 36 months and conditional changes between the time points calculated. Blood pressure was measured at 36 months. Factors possibly influencing the blood pressure were assessed using linear regression. All independent variables of interest and confounding variables were included in stepwise multiple regression to identify the model that best predicted blood pressure at 36 months.
resultsGreater conditional gains in abdominal circumference (AC) between 0-6 and 24-36 months were associated with higher systolic and diastolic blood pressures at 36 months (p<0.001). Subscapular skinfold and height gains were weakly associated with higher blood pressures, while greater weight gains between 0-6, 12-24 and 24-36 months were more strongly associated, but the dominant influences were AC gains, particularly from 0-6 to 24-36 months. Thus one SD score increases in AC between 0-6 and 24-36 months were associated with 1.59 mm Hg (95% CI 0.97 to 2.21) and 1.84 mm Hg (1.24 to 2.46) higher systolic blood pressures, respectively, and 1.04 mm Hg (0.57 to 1.51) and 1.02 mm Hg (0.56, 1.48) higher diastolic pressures, respectively.
conclusionsConditional gains in abdominal circumference, particularly within 6 months of birth and in the year preceding measurement, were more positively associated with blood pressure at 36 months than gains in other anthropometric measures. Above-average AC gains in early childhood may contribute to adult hypertension and increased cardiovascular disease risk.
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