ArticleBMJ open2014
Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study.Nutrients · 2021Pooled it
- Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.Gut and liver · 2020Pooled it
- [Low-risk alcohol drinking limits based on associated mortality.]Revista espanola de salud publica · 2020Pooled it
- Coffee Consumption and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Perspective: The Role of Beverages as a Source of Nutrients and Phytonutrients.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial.European heart journal · 2025Trial
- Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.BMJ (Clinical research ed.) · 2017Trial
- Associations of Alcohol Consumption with All-Cause and Cancer Mortalities in Patients with Type 2 Diabetes Mellitus: A Nationwide Population Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Ethanol exposure promotes tumor cell migration and angiogenesis in a mouse model of glioblastoma.Alcohol (Fayetteville, N.Y.) · 2025Article
- Alcohol use and its associated factors among Ethiopian military personnel.BMJ military health · 2024Article
- Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort.BMC medicine · 2024Article
- Sustained Hypothetical Interventions on Midlife Alcohol Consumption in Relation to All-Cause and Cancer Mortality: The Australian Longitudinal Study on Women's Health.American journal of epidemiology · 2024Article
- Article
- Mid-life alcohol consumption and survival to age 90 in men: The Tromsø Study 1979-1980 with follow-up to 2019.Scandinavian journal of public health · 2023Article
- Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer's Coordinating Center Uniform Data Set.BMC neurology · 2023Observational
- Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study.BMC medicine · 2023Article
- Alcohol consumption and risks of more than 200 diseases in Chinese men.Nature medicine · 2023Article
- A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk.European journal of epidemiology · 2022Article
- Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe.World journal of gastroenterology · 2022Review
- The effects of modest drinking on life expectancy and mortality risks: a population-based cohort study.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
39 authors at 20 institutions in 13 countries.
Funding
Abstract
objectivesTo investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death.
designThe European Prospective Investigation into Cancer and nutrition (EPIC).
setting23 centres in 10 countries.
participants380 395 men and women, free of cancer, diabetes, heart attack or stroke at enrolment, followed up for 12.6 years on average.
main outcome measures20 453 fatal events, of which 2053 alcohol-related cancers (ARC, including cancers of upper aerodigestive tract, liver, colorectal and female breast), 4187 cardiovascular diseases/coronary heart disease (CVD/CHD), 856 violent deaths and injuries. Lifetime alcohol use was assessed at recruitment.
resultsHRs comparing extreme drinkers (≥30 g/day in women and ≥60 g/day in men) to moderate drinkers (0.1-4.9 g/day) were 1.27 (95% CI 1.13 to 1.43) in women and 1.53 (1.39 to 1.68) in men. Strong associations were observed for ARC mortality, in men particularly, and for violent deaths and injuries, in men only. No associations were observed for CVD/CHD mortality among drinkers, whereby HRs were higher in never compared to moderate drinkers. Overall mortality seemed to be more strongly related to beer than wine use, particularly in men. The 10-year risks of overall death for women aged 60 years, drinking more than 30 g/day was 5% and 7%, for never and current smokers, respectively. Corresponding figures in men consuming more than 60 g/day were 11% and 18%, in never and current smokers, respectively. In competing risks analyses, mortality due to CVD/CHD was more pronounced than ARC in men, while CVD/CHD and ARC mortality were of similar magnitude in women.
conclusionsIn this large European cohort, alcohol use was positively associated with overall mortality, ARC and violent death and injuries, but marginally to CVD/CHD. Absolute risks of death observed in EPIC suggest that alcohol is an important determinant of total mortality.
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