ArticleDigestive diseases and sciences2014
Enzymatic liver function capacity correlates with disease severity of patients with liver cirrhosis: a study with the LiMAx test.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 40 citations in OpenAlex.
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- The LiMAx Test as Selection Criteria in Minimally Invasive Liver Surgery.Journal of clinical medicine · 2022Article
- Functional hepatic deterioration determined byFrontiers in cardiovascular medicine · 2022Article
- Profound decrease of liver maximum function capacity test of isoflurane sedated patients: A report of three cases.Clinical case reports · 2021Article
- CT-Based Prediction of Liver Function and Post-PVE Hypertrophy Using an Artificial Neural Network.Journal of clinical medicine · 2021Article
- Preoperative Liver Function Guiding HCC Resection in Normal and Cirrhotic Liver.Visceral medicine · 2021Article
- Morphologic Alterations Precede Functional Hepatic Impairment as Determined byFrontiers in cardiovascular medicine · 2021Article
- Validation of a new prognostic model to predict short and medium-term survival in patients with liver cirrhosis.BMC gastroenterology · 2020Article
- Article
- Enzymatic liver function measured by LiMAx - a reliable diagnostic and prognostic tool in chronic liver disease.Scientific reports · 2019Article
- Prospective Assessment of Liver Function by an Enzymatic Liver Function Test to Estimate Short-Term Survival in Patients with Liver Cirrhosis.Digestive diseases and sciences · 2019Article
- Prognostic factors of disease-free and overall survival in patients with hepatocellular carcinoma undergoing partial hepatectomy in curative intent.Langenbeck's archives of surgery · 2018Article
- Randomized clinical trial comparing liver resection with and without perioperative assessment of liver function.BJS open · 2018Article
- Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report.BMC anesthesiology · 2018Article
- Hepatobiliary MRI: Signal intensity based assessment of liver function correlated toScientific reports · 2018Article
- Liver Transplantation and Liver Resection for Cirrhotic Patients with Hepatocellular Carcinoma: Comparison of Long-Term Survivals.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Impact of liver volume and liver function on posthepatectomy liver failure after portal vein embolization- A multivariable cohort analysis.Annals of medicine and surgery (2012) · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment and quantification of actual liver function is crucial in patients with chronic liver disease to monitor disease progression and predict individual prognosis. Mathematical models, such as model for end-stage liver disease, are used for risk stratification of patients with chronic liver disease but do not include parameters that reflect the actual functional state of the liver.
aimWe aimed to evaluate the potential of a (13)C-based liver function test as a stratification tool by comparison with other liver function tests and clinical parameters in a large sample of healthy controls and cirrhotic patients.
methodsWe applied maximum liver function capacity (LiMAx) to evaluate actual liver function in 347 patients with cirrhosis and in 86 controls.
resultsLiMAx showed strong negative correlation with Child-Pugh Score (r = -0.707; p < 0.001), MELD (r = -0.686; p < 0.001) and liver function tests. LiMAx was lower in patients with liver cirrhosis compared to healthy controls [99 (57-160) µg/kg/h vs. 412 (365-479) µg/kg/h, p < 0.001] and differed among Child-Pugh classes [a: 181 (144-227) µg/kg/h, b: 96 (62-132) µg/kg/h and c: 52 (37-81) µg/kg/h; p < 0.001]. When stratified patients according to disease severity, LiMAx results were not different between cirrhotic patients and cirrhotic patients with transjugular intrahepatic portosystemic shunt.
conclusionsLiMAx appears to provide reliable information on remnant enzymatic liver function in chronic liver disease and allows graduation of disease severity.
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