Evidence map›Paper›PMID 24993663›Full record

ArticleActa diabetologica2015

Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics.

Xiao-Song He, Zhao-Xin Wang, You-Zhi Zhu, Nan Wang, Xiaoping Hu, Da-Ren Zhang, De-Fa Zhu, Jiang-Ning Zhou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  7. Diabetes and dementia: Clinical perspective, innovation, knowledge gaps.Journal of diabetes and its complications · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Xiao-Song HeCAS Key Laboratory of Brain Function and Diseases, School of Life Science, University of Science and Technology of China, 433 Huangshan Road, Hefei, 230027, Anhui, China.
Zhao-Xin Wang
You-Zhi Zhu
Nan Wang
Xiaoping Hu
Da-Ren Zhang
De-Fa Zhu
Jiang-Ning Zhou
University of Science and Technology of China · CN81th Hospital of PLA · CNAnhui Medical University · CNEmory University · USFirst Affiliated Hospital of Anhui Medical University · CN

Funding

IMPROVEMENT AND APPLICATIONS OF FUNCTIONAL MRIR01EB002009 · NIBIB · EMORY UNIVERSITY · PI HU, XIAOPING P · 2003 to 2008
$2.3M
NIBIB NIH HHS R01 EB002009NIBIB NIH HHS R01EB002009
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is well known for its adverse impacts on brain and cognition, which leads to multidimensional cognitive deficits and wildly spread cerebral structure abnormalities. However, existing literatures are mainly focused on patients with advanced age or extended T2DM duration. Therefore, it remains unclear whether and how brain function would be affected at the initial onset stage of T2DM in relatively younger population. In current study, twelve newly diagnosed middle-aged T2DM patients with no previous diabetic treatment history and twelve matched controls were recruited. Brain activations during a working memory task, the digit n-back paradigm (0-, 1- and 2-back), were obtained with functional magnetic resonance imaging and tested by repeated measures ANOVA. Whereas patients performed the n-back task comparably well as controls, significant load-by-group interactions of brain activation were found in the right dorsolateral prefrontal cortex (DLPFC), left middle/inferior frontal gyrus, and left parietal cortex, where patients exhibited hyperactivation in the 2-back, but not the 0-back or 1-back condition compared to controls. Furthermore, the severity of chronic hyperglycemia, estimated by glycosylated hemoglobin (HbA1c) level, was entered into partial correlational analyses with task-related brain activations, while controlling for the real-time influence of glucose, estimated by instant plasma glucose level measured before scanning. Significant positive correlations were found between HbA1c and brain activations in the anterior cingulate cortex and bilateral DLPFC only in patients. Taken together, these findings suggest there might be a compensatory mechanism due to brain inefficiency related to chronic hyperglycemia at the initial onset stage of T2DM.

Indexed as

Memory, Short-TermAdultBlood GlucoseBrainCase-Control StudiesDiabetes Mellitus, Type 2FemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRadiographyBlood Glucose

Identifiers

PMID24993663
PMCPMC4416650
OpenAlexW2061019354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.