ArticleThe international journal of cardiovascular imaging2014
Coronary artery calcium quantification from contrast enhanced CT using gemstone spectral imaging and material decomposition.
Article in The international journal of cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Quantification of coronary artery calcium using virtual non-contrast images derived from dual-layer spectral CT.La Radiologia medica · 2026Article
- Safety Net Reconstruction to Catch Low-Density and Low-Volume Calcifications at Photon-Counting Detector CT Using Virtual Noncontrast Imaging.Radiology. Cardiothoracic imaging · 2024Article
- Image Characteristics of Virtual Non-Contrast Series Derived from Photon-Counting Detector Coronary CT Angiography-Prerequisites for and Feasibility of Calcium Quantification.Diagnostics (Basel, Switzerland) · 2023Article
- Feasibility and accuracy of coronary artery calcium score on virtual non-contrast images derived from a dual-layer spectral detector CT: A retrospective multicenter study.Frontiers in cardiovascular medicine · 2023Article
- Measurement of enhanced vasa vasorum density in a porcine carotid model using photon counting detector CT.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- Dual-Energy Heart CT: Beyond Better Angiography-Review.Journal of clinical medicine · 2021Review
- Dual-energy CT and coronary imaging.Cardiovascular diagnosis and therapy · 2020Review
- Article
- An Image-Domain Contrast Material Extraction Method for Dual-Energy Computed Tomography.Investigative radiology · 2017Article
- Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.Advanced drug delivery reviews · 2017Review
- Cardiac CT Imaging of Plaque Vulnerability: Hype or Hope?Current cardiology reports · 2016Review
- Dual-energy computed tomography for detection of coronary artery disease.Expert review of cardiovascular therapy · 2015Review
- New Applications of Cardiac Computed Tomography: Dual-Energy, Spectral, and Molecular CT Imaging.JACC. Cardiovascular imaging · 2015Review
- Cardiovascular imaging 2014 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2015Review
- Dual-energy Computed Tomography in Coronary Artery Calcium Scoring.Heart views : the official journal of the Gulf Heart AssociationReview
- Improved Calcium Scoring at Dual-Energy Computed Tomography Angiography Using a High-Z Contrast Element and Novel Material Separation Technique.Journal of computer assisted tomographyArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the feasibility of coronary artery calcium (CAC) measurement from low-dose contrast enhanced coronary CT angiography (CCTA) as this may obviate the need for an unenhanced CT scan. 52 patients underwent unenhanced cardiac CT and prospectively ECG triggered contrast enhanced CCTA (Discovery HD 750, GE Healthcare, Milwaukee, WI, USA). The latter was acquired in single-source dual-energy mode [gemstone spectral imaging (GSI)]. Virtual unenhanced images were generated from GSI CCTA by monochromatic image reconstruction of 70 keV allowing selective iodine material suppression. CAC scores from virtual unenhanced CT were compared to standard unenhanced CT including a linear regression model. After iodine subtraction from the contrast enhanced CCTA the attenuation in the ascending aorta decreased significantly from 359 ± 61 to 54 ± 8 HU (P < 0.001), the latter comparing well to the value of 64 ± 55 HU found in the standard unenhanced CT (P = ns) confirming successful iodine subtraction. After introducing linear regression formula the mean values for Agatston, Volume and Mass scores of virtual unenhanced CT were 187 ± 321, 72 ± 114 mm(3), and 27 ± 46 mg/cm(3), comparing well to the values from standard unenhanced CT (187 ± 309, 72 ± 110 mm(3), and 27 ± 45 mg/cm(3)) yielding an excellent correlation (r = 0.96, r = 0.96, r = 0.92; P < 0.001). Mean estimated radiation dose revealed 0.83 ± 0.02 mSv from the unenhanced CT and 1.70 ± 0.53 mSv from the contrast enhanced CCTA. Single-source dual-energy scanning with GSI allows CAC quantification from low dose contrast enhanced CCTA by virtual iodine contrast subtraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.