ArticleScientific reports2014
Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Herbaria provide a valuable resource for obtaining informative mRNA.Genome research · 2026Article
- Investigating food production-associated DNA methylation changes in paleogenomes: Lack of consistent signals beyond technical noise.Evolutionary applications · 2024Article
- How ancient RNA survives and what we can learn from it.Nature reviews. Molecular cell biology · 2024Article
- Small RNA-mediated DNA methylation during plant reproduction.The Plant cell · 2023Review
- Performance and automation of ancient DNA capture with RNA hyRAD probes.Molecular ecology resources · 2022Article
- Article
- The Global Museum: natural history collections and the future of evolutionary science and public education.PeerJ · 2020Article
- Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival.PLoS biology · 2019Article
- Paleogenomics: reconstruction of plant evolutionary trajectories from modern and ancient DNA.Genome biology · 2019Article
- Successful reconstruction of whole mitochondrial genomes from ancient Central America and Mexico.Scientific reports · 2017Article
- Small RNA Activity in Archeological Barley Shows Novel Germination Inhibition in Response to Environment.Molecular biology and evolution · 2017Article
- Inferring Past Environments from Ancient Epigenomes.Molecular biology and evolution · 2017Article
- Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing.GigaScience · 2017Article
- Review
- Review
- Assessing elements of an extended evolutionary synthesis for plant domestication and agricultural origin research.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Toward high-resolution population genomics using archaeological samples.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Review
- Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle.Genome biology · 2015Article
- Pros and cons of methylation-based enrichment methods for ancient DNA.Scientific reports · 2015Article
- Reconstructing ancient genomes and epigenomes.Nature reviews. Genetics · 2015Review
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6 authors.
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Abstract
Genomic methylation is variable under biotic and abiotic stresses in plants. In particular, viral infection is thought to significantly increase genomic methylation with particularly high activity around transposable elements. Here we present the genomic methylation profiles of grains of archaeological barley (Hordeum vulgare) from several strata from a site in southern Egypt, from the Napatan to the Islamic periods (800 BCE - 1812 CE). One sample tested positive for viral infection and exhibits an unusually high degree of genomic methylation compared to the rest. A decreasing trend in global methylation levels according to deposition date shows in-situ de-methylation of 5-methylcytosine, which can be described as a diagenetic process. This is most likely a deamination mediated de-methylation process and is expected to lead to 5 mC > T base modifications in addition to the C > U modifications due to cytosine deamination, so represents a time-dependent process of DNA diagenesis in ancient DNA.
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