ArticleBMC microbiology2014
Complete genome assembly and characterization of an outbreak strain of the causative agent of swine erysipelas--Erysipelothrix rhusiopathiae SY1027.
Article in BMC microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- An ancient Erysipelothrix rhusiopathiae genome recovered from 1400-year-old human remains in the Northern Caucasus.Scientific reports · 2026Article
- Prophage φEr670 and Genomic Island GI_Er147 as Carriers of Resistance Genes inInternational journal of molecular sciences · 2025Article
- Serotypes, Antimicrobial Susceptibility, and Potential Mechanisms of Resistance Gene Transfer inInternational journal of molecular sciences · 2024Article
- Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes inInternational journal of molecular sciences · 2024Article
- Phenotypic and Genotypic Characterization of a Highly VirulentTransboundary and emerging diseases · 2024Article
- Cecal Microbial Succession and Its Apparent Association with Nutrient Metabolism in Broiler Chickens.mSphere · 2023Article
- Population Structure and Genomic Characteristics of AustralianMicroorganisms · 2023Article
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- Characterization ofMicroorganisms · 2021Article
- Comparative genomics of a novel clade shed light on the evolution of the genus Erysipelothrix and characterise an emerging species.Scientific reports · 2021Article
- Comparative genome analysis ofMicrobial genomics · 2020Article
- Comparative Genome Analysis of a PathogenicVeterinary sciences · 2020Article
- Genomic and Immunogenic Protein Diversity ofFrontiers in microbiology · 2020Article
- Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis.Applied and environmental microbiology · 2017Article
- Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae.PloS one · 2017Article
- Article
- Proteomic and Transcriptomic Analyses of Swine Pathogen Erysipelothrix rhusiopathiae Reveal Virulence Repertoire.PloS one · 2016Article
- Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China.Emerging microbes & infections · 2015Article
- Insights into the Role of Erysipelotrichaceae in the Human Host.Frontiers in cellular and infection microbiology · 2015Article
- Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErysipelothrix rhusiopathiae is the causative agent of animal erysipelas and, to a fewer occurrences, human erysipeloid. It is ubiquitous in nature and commensal in diverse species of animals, wild or domestic, from mammals and birds to reptiles and fish. Mechanisms of its virulence and pathogenicity are poorly understood.
resultsMaking use of the complete genome sequencing of E. rhusiopathiae strain SY1027 and comparative genome analysis between the three highly pathogenic strains (SY1027, Fujisawa and ATCC19414), the genomic structure and putative functional elements, such as pathogenicity island (PAI)-like regions, potential virulence factors and horizontal transferring genes of the bacteria are identified. Strain SY1027 genome is 1,752,910 base pairs long, just 30 kilobases smaller than strain Fujisawa, with the same GC level of 36.36%. It contains 1,845 open reading frames (ORF) predicted by GLIMMER 3.02, of which 1,775 were annotated by PGAAP, 1,757 (~95.23%) were annotated by NCBI nr blast, 1,209 by COG database and 1,076 by KEGG database. 37 potential virulence factors were annotated in strain SY1027 by VFDB, while 19 (~51.35%) of them are common in the 2 strains, 7 of which are potentially related to antibiotic resistance and highly conserved (~98-100% match identity (ID)) amongst the three strains of E. rhusiopathiae and modestly homologous to other gastrointestinal tract-inhabiting Firmicutes (~40% match ID), e.g. Clostridium spp., Enterococcus spp. Genomic island- and pathogenicity island-like regions were also predicted, in which some showed association with tRNA and potential virulence factors.
conclusionComplete genome sequencing of Erysipelothrix rhusiopathiae, the causative agent of animal erysipelas, was performed. Molecular identification of various genomic elements pave the way to the better understanding of mechanisms underlying metabolic capabilities, pathogenicity of swine erysipelas and prospective vaccine targets besides the widely used SpaA antigens.
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