ArticleInternational journal of molecular medicine2014
Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.
Article in International journal of molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Trial
- FMT alleviates multidrug-resistantFrontiers in microbiology · 2026Article
- Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Interleukin-11 receptor is an alternative α-receptor for interleukin-6 and the chimeric cytokine IC7.The FEBS journal · 2025Article
- The Potential of the Probiotic IsolateFood science & nutrition · 2025Article
- Leukocyte dysfunction and reduced CTLA-4 expression are associated with perianal Crohn's disease.Clinical and experimental immunology · 2024Observational
- IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages.Frontiers in immunology · 2024Article
- Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis.Scientific reports · 2022Article
- Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.Scientific reports · 2021Article
- Review
- IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors.Journal for immunotherapy of cancer · 2021Article
- Potential Mechanism Prediction of Herbal Medicine for Pulmonary Fibrosis Associated with SARS-CoV-2 Infection Based on Network Analysis and Molecular Docking.Frontiers in pharmacology · 2021Article
- Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.Journal of microbiology and biotechnology · 2020Article
- Teasaponin Ameliorates Murine Colitis by Regulating Gut Microbiota and Suppressing the Immune System Response.Frontiers in medicine · 2020Article
- Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells.Leukemia · 2019Article
- Association between Interleukin-6 Levels and Perioperative Fatigue in Gastric Adenocarcinoma Patients.Journal of clinical medicine · 2019Article
- Dietary Fiber Pectin Ameliorates Experimental Colitis in a Neutral Sugar Side Chain-Dependent Manner.Frontiers in immunology · 2019Article
- Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Myosin 1F Regulates M1-Polarization by Stimulating Intercellular Adhesion in Macrophages.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)‑deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28 (IL-30) and ciliary neurotrophic factor (CNTF) have been identified as additional low‑affinity ligands of the IL-6R/gp130/LIFR complex. IL-6 plays an inflammatory and regenerative role in inflammatory bowel disease (IBD). In the present study, we compared Il-6r-deficient mice with mice treated with neutralizing IL-6 monoclonal antibody (mAb) in a model of dextran sodium sulfate (DSS)-induced colitis. Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase. Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice. Our data suggest that IL-6 and IL-6R have an additional role in colitis, apart from the IL-6/IL-6R classic and trans-signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.