ArticleAmerican journal of physiology. Heart and circulatory physiology2014
Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Chorioamnionitis appears not to be a Risk Factor for Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.Scientific reports · 2016Pooled it
- Patent Ductus Arteriosus in Extremely Preterm Infants: Update on Current Diagnostic and Treatment Options.Current treatment options in cardiovascular medicine · 2025Review
- Contemporary fluid management, humidity, and patent ductus arteriosus management strategy for premature infants among 336 hospitals in Asia.Frontiers in pediatrics · 2024Article
- A novel role for PGEAmerican journal of physiology. Heart and circulatory physiology · 2023Article
- Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy.Pharmacological research · 2023Article
- The impact of early empirical antibiotics treatment on clinical outcome of very preterm infants: a nationwide multicentre study in China.Italian journal of pediatrics · 2023Article
- The Association of Patent Ductus Arteriosus with Inflammation: A Narrative Review of the Role of Inflammatory Biomarkers and Treatment Strategy in Premature Infants.International journal of molecular sciences · 2022Review
- Mouse models of patent ductus arteriosus (PDA) and their relevance for human PDA.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Association of chorioamnionitis and patent ductus arteriosus in a national U.S. cohort.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Surgical ligation of patent ductus arteriosus in preterm neonates weighing less than 1500g: a 9-year single center experience.Journal of cardiothoracic surgery · 2020Article
- Early Urinary Metabolomics in Patent Ductus Arteriosus Anticipates the Fate: Preliminary Data.Frontiers in pediatrics · 2020Article
- Genetic variants associated with patent ductus arteriosus in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Diagnosis and Management of Patent Ductus Arteriosus.NeoReviews · 2018Article
- IL-17 in neonatal health and disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Review
- Article
- Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.American journal of physiology. Heart and circulatory physiology · 2016Article
- [Risk factors for patent ductus arteriosus in early preterm infants: a case-control study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Gentamicin in Neonates with Hemodynamically Significant Patent Ductus Arteriosus.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Sepsis is strongly associated with patency of the ductus arteriosus (PDA) in critically ill newborns. Inflammation and the aminoglycoside antibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unknown. We examined whether: 1) lipopolysaccharide (LPS) or inflammatory cytokines cause relaxation of the ex vivo mouse DA; 2) the aminoglycosides gentamicin, tobramycin, or amikacin causes DA relaxation; and 3) newborn infants treated with aminoglycosides have an increased risk of symptomatic PDA (sPDA). Changes in fetal mouse DA tone were measured by pressure myography in response to LPS, TNF-α, IFN-γ, macrophage-inflammatory protein 2, IL-15, IL-13, CXC chemokine ligand 12, or three aminoglycosides. A clinical database of inborn patients of all gestations was analyzed for association between sPDA and aminoglycoside treatment. Contrary to expectation, neither LPS nor any of the inflammatory mediators caused DA relaxation. However, each of the aminoglycosides caused concentration-dependent vasodilation in term and preterm mouse DAs. Pretreatment with indomethacin and N-(G)-nitro-L-arginine methyl ester did not prevent gentamicin-induced DA relaxation. Gentamicin-exposed DAs developed less oxygen-induced constriction than unexposed DAs. Among 488,349 infants who met the study criteria, 40,472 (8.3%) had sPDA. Confounder-adjusted odds of sPDA were higher in gentamicin-exposed infants, <25 wk and >32 wk. Together, these findings suggest that factors other than inflammation contribute to PDA. Aminoglycoside-induced vasorelaxation and inhibition of oxygen-induced DA constriction support the paradox that antibiotic treatment of sepsis may contribute to DA relaxation. This association was also found in newborn infants, suggesting that antibiotic selection may be an important consideration in efforts to reduce sepsis-associated PDA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.