ArticleBMC genomics2014
Quack leptin.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- A Bird's-Eye Overview of Leptin and Female Reproduction -with Mammalian Comparisons.The journal of poultry science · 2025Review
- A genome-wide association analysis for body weight at 35 days measured on 137,343 broiler chickens.Genetics, selection, evolution : GSE · 2021Article
- Sequence properties of certain GC rich avian genes, their origins and absence from genome assemblies: case studies.BMC genomics · 2019Article
- Avian Expression Patterns and Genomic Mapping Implicate Leptin in Digestion and TNF in Immunity, Suggesting That Their Interacting Adipokine Role Has Been Acquired Only in MammalsInternational journal of molecular sciences · 2019Article
- Peripherally injected ghrelin and leptin reduce food hoarding and mass gain in the coal tit (Proceedings. Biological sciences · 2018Article
- Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction.BMC genomics · 2018Article
- Mapping of leptin and its syntenic genes to chicken chromosome 1p.BMC genetics · 2017Article
- Regulation of Agouti-Related Protein and Pro-Opiomelanocortin Gene Expression in the Avian Arcuate Nucleus.Frontiers in endocrinology · 2017Review
- Hypothalamic Agouti-Related Peptide mRNA is Elevated During Natural and Stress-Induced Anorexia.Journal of neuroendocrinology · 2015Article
- Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus).PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA LEP transcript up-regulated in lungs of ducks (Anas platyrhynchos) infected by avian influenza A virus was recently described in the Nature Genetics manuscript that reported the duck genome. In vertebrates, LEP gene symbol is reserved for leptin, the key regulator of energy balance in mammals.
resultsLaunching an extensive search for this gene in the genome data that was submitted to the public databases along with duck genome manuscript and extending this search to all avian genomes in the whole-genome shotgun-sequencing database, we were able to report the first identification of coding sequences capable of encoding the full leptin protein precursor in wild birds. Gene structure, synteny and sequence-similarity (up to 54% identity and 68% similarity) to reptilian leptin evident in falcons (Falco peregrinus and cherrug), tits (Pseudopodoces humilis), finches (Taeniopygia guttata) and doves (Columba livia) confirmed that the bird leptin was a true ortholog of its mammalian form. Nevertheless, in duck, like other domestic fowls the LEP gene was not identifiable.
conclusionLack of the LEP gene in poultry suggests that birds that have lost it are particularly suited to domestication. Identification of an intact avian gene for leptin in wild birds might explain in part the evolutionary conservation of its receptor in leptin-less fowls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.