ArticleJournal of mathematical biology2015
Adaptive gene introgression after secondary contact.
Article in Journal of mathematical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
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- Adaptive alien genes are maintained amid a vanishing introgression footprint in a sea squirt.Evolution letters · 2024Article
- The fitness of an introgressing haplotype changes over the course of divergence and depends on its size and genomic location.PLoS biology · 2023Article
- Inference of Gene Flow between Species under Misspecified Models.Molecular biology and evolution · 2022Article
- Hybrid fitness effects modify fixation probabilities of introgressed alleles.G3 (Bethesda, Md.) · 2022Article
- Hybridization may aid evolutionary rescue of an endangered East African passerine.Evolutionary applications · 2022Article
- A dense linkage map for a large repetitive genome: discovery of the sex-determining region in hybridizing fire-bellied toads (Bombina bombina and Bombina variegata).G3 (Bethesda, Md.) · 2021Article
- The genomic consequences of hybridization.eLife · 2021Review
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- The impact of global selection on local adaptation and reproductive isolation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Evolution of strong reproductive isolation in plants: broad-scale patterns and lessons from a perennial model group.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- VolcanoFinder: Genomic scans for adaptive introgression.PLoS genetics · 2020Article
- Eukaryote hybrid genomes.PLoS genetics · 2019Article
- Article
- Article
- Fine scale mapping of genomic introgressions within the Drosophila yakuba clade.PLoS genetics · 2017Article
- Article
- The Role of Recombination in Evolutionary Rescue.Genetics · 2016Article
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Authors and funding
3 authors.
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Abstract
By hybridization and backcrossing, alleles can surmount species boundaries and be incorporated into the genome of a related species. This introgression of genes is of particular evolutionary relevance if it involves the transfer of adaptations between populations. However, any beneficial allele will typically be associated with other alien alleles that are often deleterious and hamper the introgression process. In order to describe the introgression of an adaptive allele, we set up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious alleles. Based on the theory of reducible multitype branching processes, we derive a recursive expression for the establishment probability of the beneficial allele after a single hybridization event. We furthermore study the probability that slightly deleterious alleles hitchhike to fixation. The key to the analysis is a split of the process into a stochastic phase in which the advantageous alleles establishes and a deterministic phase in which it sweeps to fixation. We thereafter apply the theory to a set of biologically relevant scenarios such as introgression in the presence of many unlinked or few closely linked deleterious alleles. A comparison to computer simulations shows that the approximations work well over a large parameter range.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.