ArticleArchives of disease in childhood1989
Association of mineral composition of neonatal intravenous feeding solutions and metabolic bone disease of prematurity.
Article in Archives of disease in childhood, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 34 citations in OpenAlex.
- Bone mineralisation in premature infants cannot be predicted from serum alkaline phosphatase or serum phosphate.Archives of disease in childhood. Fetal and neonatal edition · 2002Trial
- Graphical user interface for a neonatal parenteral nutrition decision support system.Proceedings. AMIA Symposium · 2000Article
- Nutritional aspects of metabolic bone disease in the newborn.Archives of disease in childhood. Fetal and neonatal edition · 1996Review
- Calcium and phosphorus solubility in neonatal intravenous feeding solutions.Archives of disease in childhood · 1990Article
- Acid-base state of the preterm infant and the formulation of intravenous feeding solutions.Archives of disease in childhood · 1990Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the effects of increasing the mineral content of parenteral nutrition solutions on the biochemical and radiological indicators of metabolic bone disease of prematurity 27 neonates who required parenteral nutrition were sequentially allocated to receive either a standard solution (group 1) or one with an increased mineral content (group 2). The 13 patients in group 1 received 0.68 mmol/kg/day of calcium and 0.61 mmol/kg/day of phosphorus, and the 14 in group 2 received 1.25 and 1.20 mmol/kg/day, respectively. The two groups did not differ significantly in the severity of their illness measured by birth weight, gestational age, duration of parenteral nutrition or ventilation, or the amount of supplementary oxygen required. In patients in group 2 the median plasma phosphate concentration was higher, the plasma alkaline phosphatase activity was lower, and there was less radiological evidence of rickets. There were no complications caused by excess calcium and phosphorus, and the rate of growth was similar in both groups. We conclude that an increased mineral content in parenteral nutrition solutions reduces the severity of metabolic bone disease in sick infants who require this form of nutrition.
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