ArticlePloS one2014
Polygenic risk predicts obesity in both white and black young adults.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.Behavior genetics · 2021Pooled it
- The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.EMBO reports · 2026Article
- Overestimated prediction using polygenic prediction derived from summary statistics.BMC genomic data · 2023Article
- Identification of potential genetic Loci and polygenic risk model for Budd-Chiari syndrome in Chinese population.iScience · 2023Article
- Development of a genetic risk score for obesity predisposition evaluation.Molecular genetics and genomics : MGG · 2022Article
- Do we measure or compute polygenic risk scores? Why language matters.Human genetics · 2022Article
- Incarceration, polygenic risk, and depressive symptoms among males in late adulthood.Social science research · 2022Article
- Exploring Rural-Urban Differences in Polygenic Associations for Health among Older Adults in the United States.Journal of rural social sciences · 2022Article
- Educational attainment polygenic score predicts inhibitory control and academic skills in early and middle childhood.Genes, brain, and behavior · 2021Article
- Artificial image objects for classification of schizophrenia with GWAS-selected SNVs and convolutional neural network.Patterns (New York, N.Y.) · 2021Article
- Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated.Development and psychopathology · 2021Article
- Utilizing genome wide data to highlight the social behavioral pathways to health: The case of obesity and cardiovascular health among older adults.Social science & medicine (1982) · 2021Article
- Intersections of Adolescent Well-Being: School, Work, and Weight Status in Brazil.Journal of health and social behavior · 2021Article
- Comparison of risk allele frequencies of single nucleotide polymorphisms associated with age-related macular degeneration in different ethnic groups.BMC ophthalmology · 2021Article
- Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.PloS one · 2020Article
- Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.Current diabetes reports · 2019Review
- Genetic risk, body mass index, and weight control behaviors: Unlocking the triad.The International journal of eating disorders · 2019Article
- Maternal BMI-Increasing Genetic Risk Score and Fetal Weights among Diverse US Ethnic Groups.Obesity (Silver Spring, Md.) · 2019Article
- Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States.Demography · 2018Article
- Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo test transethnic replication of a genetic risk score for obesity in white and black young adults using a national sample with longitudinal data. DESIGN AND
methodsA prospective longitudinal study using the National Longitudinal Study of Adolescent Health Sibling Pairs (n = 1,303). Obesity phenotypes were measured from anthropometric assessments when study members were aged 18-26 and again when they were 24-32. Genetic risk scores were computed based on published genome-wide association study discoveries for obesity. Analyses tested genetic associations with body-mass index (BMI), waist-height ratio, obesity, and change in BMI over time.
resultsWhite and black young adults with higher genetic risk scores had higher BMI and waist-height ratio and were more likely to be obese compared to lower genetic risk age-peers. Sibling analyses revealed that the genetic risk score was predictive of BMI net of risk factors shared by siblings. In white young adults only, higher genetic risk predicted increased risk of becoming obese during the study period. In black young adults, genetic risk scores constructed using loci identified in European and African American samples had similar predictive power.
conclusionCumulative information across the human genome can be used to characterize individual level risk for obesity. Measured genetic risk accounts for only a small amount of total variation in BMI among white and black young adults. Future research is needed to identify modifiable environmental exposures that amplify or mitigate genetic risk for elevated BMI.
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Registered trials
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