ReviewCurrent opinion in nephrology and hypertension2014
Renalase: its role as a cytokine, and an update on its association with type 1 diabetes and ischemic stroke.
Review in Current opinion in nephrology and hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Cardiovascular risk assessed using the SCORE system and blood renalase concentration in the Polish subpopulation of the PURE study.Scientific reports · 2026Article
- RNLS hypomethylation as a potential epigenetic marker of lung cancer metastasis: an epigenome-wide association study.British journal of cancer · 2026Article
- The Role of Renalase in Cardiovascular Disease: A Comprehensive Review of Its Molecular Biology, Genetic Associations, and Clinical Significance.Life (Basel, Switzerland) · 2025Review
- Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024Review
- Renalase protects against podocyte injury by inhibiting oxidative stress and apoptosis in diabetic nephropathy.Open life sciences · 2024Article
- The early diagnostic value of serum renalase level in diabetic kidney disease and diabetic macroangiopathy: a retrospective case-control study.Therapeutic advances in chronic disease · 2024Article
- Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration.International journal of molecular sciences · 2023Article
- Plasma renalase levels are associated with the development of acute pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023Article
- A Common Genetic Factor Underlies Genetic Risk for Gynaecological and Reproductive Disorders and Is Correlated with Risk to Depression.Neuroendocrinology · 2023Article
- Renalase: a novel regulator of cardiometabolic and renal diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Advances and Challenges in Biomarkers Use for Coronary Microvascular Dysfunction: From Bench to Clinical Practice.Journal of clinical medicine · 2022Review
- Inhibition of renalase drives tumour rejection by promoting T cell activation.European journal of cancer (Oxford, England : 1990) · 2022Article
- Association of simple renal cysts with metabolic syndrome in adults.Frontiers in public health · 2022Article
- Review
- The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients.International journal of environmental research and public health · 2021Article
- Renalase in Haemodialysis Patients with Chronic Kidney Disease.Journal of clinical medicine · 2021Article
- The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.Disease markers · 2021Article
- Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality.Kidney international reports · 2020Article
- Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease.The Korean journal of internal medicine · 2019Article
- Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia.International journal of cardiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
purpose of reviewRemarkable progress has been achieved over the past 2 years in understanding the cellular actions of renalase, its pathophysiology and potential therapeutic utility. RECENT
findingsThere has been a paradigm shift in our thinking about the mechanisms underlying the cellular actions of renalase. We now understand that, independent of its enzymatic properties, renalase functions as a signaling molecule, a cytokine that interacts with a yet-to-be identified plasma membrane receptor(s) to activate protein kinase B and the mitogen-activated protein kinase pathway. These signaling properties are critical to its cytoprotective effects. New information regarding renalase's enzymatic function as an α-nicotinamide adenine dinucleotide oxidase/anomerase will be reviewed. Lastly, we will discuss the association of certain single nucleotide polymorphisms in the renalase gene with type 1 diabetes and with ischemic stroke, and the clinical implications of these findings. SUMMARY: The consistent association of renalase single nucleotide polymorphisms and the development of type 1 diabetes is a great interest particularly because we now understand that renalase functions as a cytokine. Future work on renalase should focus on exploring the identity of its receptor(s), and its potential role as an immune modulator.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.