ArticleBioconjugate chemistry2014
Redox-triggered self-assembly of gadolinium-based MRI probes for sensing reducing environment.
Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
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- Smart Molecular Imaging and Theranostic Probes by Enzymatic Molecular In Situ Self-Assembly.JACS Au · 2024Review
- Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells.Journal of the American Chemical Society · 2024Article
- Biocompatible strategies for peptide macrocyclisation.Chemical science · 2024Review
- Activatable Nanoparticles: Recent Advances in Redox-Sensitive Magnetic Resonance Contrast Agent Candidates Capable of Detecting Inflammation.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Enzymatic Noncovalent Synthesis.Chemical reviews · 2020Review
- Reduction TriggeredJournal of the American Chemical Society · 2020Article
- Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging.Chembiochem : a European journal of chemical biology · 2020Article
- Exploring the Condensation Reaction between Aromatic Nitriles and Amino Thiols To Optimize In Situ Nanoparticle Formation for the Imaging of Proteases and Glycosidases in Cells.Angewandte Chemie (International ed. in English) · 2020Article
- Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly.Research (Washington, D.C.) · 2020Article
- Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging.Journal of the American Chemical Society · 2019Article
- Screening of ligands for redox-active europium using magnetic resonance imaging.Bioorganic & medicinal chemistry · 2018Article
- Instructed-Assembly (iA): A Molecular Process for Controlling Cell Fate.Bulletin of the Chemical Society of Japan · 2018Article
- Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.Chemical Society reviews · 2017Review
- Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole.Beilstein journal of organic chemistry · 2016Article
- Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent.ACS nano · 2015Article
- A neutral polydisulfide containing Gd(III) DOTA monoamide as a redox-sensitive biodegradable macromolecular MRI contrast agent.Contrast media & molecular imagingArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Controlled self-assembly of small molecule gadolinium (Gd) complexes into nanoparticles (GdNPs) is emerging as an effective approach to design activatable magnetic resonance imaging (MRI) probes and amplify the r₁ relaxivity. Herein, we employ a reduction-controlled macrocyclization reaction and self-assembly to develop a redox activated Gd-based MRI probe for sensing a reducing environment. Upon disulfide reduction at physiological conditions, an acyclic contrast agent 1 containing dual Gd-chelates undergoes intramolecular macrocyclization to form rigid and hydrophobic macrocycles, which subsequently self-assemble into GdNPs, resulting in a ∼60% increase in r₁ relaxivity at 0.5 T. Probe 1 has high r₁ relaxivity (up to 34.2 mM(-1) s(-1) per molecule at 0.5 T) upon activation, and also shows a high sensitivity and specificity for MR detection of thiol-containing biomolecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.