ArticlePloS one2014
Amniotic membrane grafts for the prevention of esophageal stricture after circumferential endoscopic submucosal dissection.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Prevention of Esophageal Stricture After Endoscopic Submucosal Dissection: A Systematic Review.World journal of surgery · 2015Pooled it
- Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation.Scientific reports · 2017Trial
- Experimental esophageal reconstruction in dogs using autologous platelet-rich plasma-augmented acellular amniotic membrane scaffold.Open veterinary journal · 2026Article
- Combined treatment of refractory benign stricture after esophageal endoscopic mucosal dissection: A case report.World journal of clinical cases · 2023Article
- Article
- Biological properties and surgical applications of the human amniotic membrane.Frontiers in bioengineering and biotechnology · 2022Review
- Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering.Regenerative therapy · 2021Article
- Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature.Journal of clinical medicine · 2020Review
- Stenting to prevent esophageal stricture after circumferential endoscopic submucosal dissection: an experimental study.Endoscopy international open · 2020Article
- Esophageal regenerative therapy using cell sheet technology.Regenerative therapy · 2020Review
- Strategies to prevent stricture after esophageal endoscopic submucosal dissection.Annals of translational medicine · 2019Review
- Long-term efficacy and safety of intralesional steroid injection plus oral steroid administration in preventing stricture after endoscopic submucosal dissection for esophageal epithelial neoplasms.Surgical endoscopy · 2019Article
- Article
- Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection.World journal of gastroenterology · 2017Review
- ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection.Journal of visualized experiments : JoVE · 2017Article
- Cell Sheet Transplantation for Esophageal Stricture Prevention after Endoscopic Submucosal Dissection in a Porcine Model.PloS one · 2016Article
- Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm.World journal of gastroenterology · 2015Review
- Prevention of esophageal stenosis after large endoscopic submucosal dissection: is there a better way to use steroids?Endoscopy international open · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe prevention of esophageal strictures following circumferential mucosal resection remains a major clinical challenge. Human amniotic membrane (AM) is an easily available material, which is widely used in ophthalmology due to its wound healing, anti-inflammatory and anti-fibrotic properties. We studied the effect of AM grafts in the prevention of esophageal stricture after endoscopic submucosal dissection (ESD) in a swine model. ANIMALS AND
methodsIn this prospective, randomized controlled trial, 20 swine underwent a 5 cm-long circumferential ESD of the lower esophagus. In the AM Group (n = 10), amniotic membrane grafts were placed on esophageal stents; a subgroup of 5 swine (AM 1 group) was sacrificed on day 14, whereas the other 5 animals (AM 2 group) were kept alive. The esophageal stent (ES) group (n = 5) had ES placement alone after ESD. Another 5 animals served as a control group with only ESD.
resultsThe prevalence of symptomatic strictures at day 14 was significantly reduced in the AM group and ES groups vs. the control group (33%, 40% and 100%, respectively, p = 0.03); mean esophageal diameter was 5.8±3.6 mm, 6.8±3.3 mm, and 2.6±1.7 mm for AM, ES, and control groups, respectively. Median (range) esophageal fibrosis thickness was 0.87 mm (0.78-1.72), 1.19 mm (0.28-1.95), and 1.65 mm (0.7-1.79) for AM 1, ES, and control groups, respectively. All animals had developed esophageal strictures by day 35.
conclusionsThe anti-fibrotic effect of AM on esophageal wound healing after ESD delayed the development of esophageal stricture in our model. However, this benefit was of limited duration in the conditions of our study.
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