ArticlePloS one2014
Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- TRPV4 Activation during Guinea Pig Airway Smooth Muscle Contraction Promotes CaPharmaceuticals (Basel, Switzerland) · 2024Article
- Relaxation Effect ofJournal of medicinal food · 2021Article
- Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs.Bioscience reports · 2020Article
- Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle.Frontiers in pharmacology · 2019Article
- Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle.Scientific reports · 2018Article
- Article
- Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.British journal of pharmacology · 2017Article
- Bitter taste receptors as targets for tocolytics in preterm labor therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction.BMC complementary and alternative medicine · 2017Article
- Distinct Effects of CaInternational journal of biological sciences · 2017Article
- Chloroform Extract ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Chloroquine inhibits CaCell & bioscience · 2017Article
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms.Oncotarget · 2016Article
- Cortex phellodendri Extract Relaxes Airway Smooth Muscle.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Relaxant action of plumula nelumbinis extract on mouse airway smooth muscle.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Bitter tastants can induce relaxation in precontracted airway smooth muscle by activating big-conductance potassium channels (BKs) or by inactivating voltage-dependent L-type Ca2+ channels (VDLCCs). In this study, a new pathway for bitter tastant-induced relaxation was defined and investigated. We found nifedipine-insensitive and bitter tastant chloroquine-sensitive relaxation in epithelium-denuded mouse tracheal rings (TRs) precontracted with acetylcholine (ACH). In the presence of nifedipine (10 µM), ACH induced cytosolic Ca2+ elevation and cell shortening in single airway smooth muscle cells (ASMCs), and these changes were inhibited by chloroquine. In TRs, ACH triggered a transient contraction under Ca2+-free conditions, and, following a restoration of Ca2+, a strong contraction occurred, which was inhibited by chloroquine. Moreover, the ACH-activated whole-cell and single channel currents of non-selective cation channels (NSCCs) were blocked by chloroquine. Pyrazole 3 (Pyr3), an inhibitor of transient receptor potential C3 (TRPC3) channels, partially inhibited ACH-induced contraction, intracellular Ca2+ elevation, and NSCC currents. These results demonstrate that NSCCs play a role in bitter tastant-induced relaxation in precontracted airway smooth muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.