ArticleThe Journal of investigative dermatology2014
Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.European journal of endocrinology · 2022Trial
- Neuro-immune Crosstalk in Atopic Dermatitis: A Multiaxial Regulatory Network and Novel Therapeutic Perspectives.Clinical reviews in allergy & immunology · 2026Review
- Exploring the Relationship Between Psychiatric Illness and Dermatological Disorders: A Narrative Review.Cureus · 2025Review
- The role of psychological stress in the pathogenesis of psoriasis.Frontiers in medicine · 2025Review
- Association of Psychological Stress With Skin Symptoms Among the Population in Saudi Arabia: A Cross-Sectional Study.Cureus · 2023Article
- Serum cortisol levels and adrenal gland size in patients with chronic obstructive pulmonary disease.American journal of translational research · 2021Article
- Non-invasive Approaches for the Diagnosis of Autoimmune/Autoinflammatory Skin Diseases-A Focus on Psoriasis andFrontiers in immunology · 2019Review
- Relationship between Hand Eczema Severity and Occupational Stress: A Cross-Sectional Study.Dermatology research and practice · 2019Article
- Hypertrophic Scar Severity at Autograft Sites Is Associated With Increased Pain and Itch After Major Thermal Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2018Article
- The influence of exposome on acne.Journal of the European Academy of Dermatology and Venereology : JEADV · 2018Review
- Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis.Brain, behavior, and immunity · 2018Article
- Association of psychological stress with skin symptoms among medical students.Saudi medical journal · 2018Article
- Association between Stress and the HPA Axis in the Atopic Dermatitis.International journal of molecular sciences · 2017Review
- Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic-Pituitary-Adrenal (HPA) Axis.The Journal of investigative dermatology · 2015Article
- UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo.Experimental dermatology · 2015Article
- Stressing the steroids in skin: paradox or fine-tuning?The Journal of investigative dermatology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the host, but the current medical paradigm holds that PS exacerbates systemic and cutaneous inflammatory disorders. Although the adverse consequences of PS are usually attributed to neuroimmune mechanisms, PS also stimulates an increase in endogenous glucocorticoids (GCs) that compromises permeability barrier homeostasis, stratum corneum cohesion, wound healing, and epidermal innate immunity in normal skin. Yet, if such PS-induced increases in GC were uniformly harmful, natural selection should have eliminated this component of the stress response. Hence, we hypothesized here instead that stress-induced elevations in endogenous GC could benefit, rather than aggravate, cutaneous function and reduce inflammation in three immunologically diverse mouse models of inflammatory diseases. Indeed, superimposed exogenous (motion-restricted) stress reduced, rather than aggravated inflammation and improved epidermal function in all three models, even normalizing serum IgE levels in the atopic dermatitis model. Elevations in endogenous GC accounted for these apparent benefits, because coadministration of mifepristone prevented stress-induced disease amelioration. Thus, exogenous stress can benefit rather than aggravate cutaneous inflammatory dermatoses through the anti-inflammatory activity of increased endogenous GC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.