ArticlePLoS genetics2014
Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The mosaicism of Cas-induced mutations and pleiotropic effects of scarlet gene in an emerging model system.Heredity · 2025Article
- Deep conservation complemented by novelty and innovation in the insect eye ground plan.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative transcriptomic analysis primarily explores the molecular mechanism of compound eye formation in Neocaridina denticulata sinensis.BMC genomics · 2024Article
- Efficient CRISPR genome editing and integrative genomic analyses reveal the mosaicism of Cas-induced mutations and pleiotropic effects ofbioRxiv : the preprint server for biology · 2024Article
- Analysis of the genome-editing activity of microinjected CRISPR/Cas9 ribonucleoprotein complexes inmicroPublication biology · 2024Article
- Exploring the molecular makeup of support cells in insect camera eyes.BMC genomics · 2023Article
- Global Gene Expression Analysis Reveals Complex Cuticle Organization of the Tribolium Compound Eye.Genome biology and evolution · 2023Article
- Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.PLoS genetics · 2021Article
- Evolutionary conservation of opsin gene expression patterns in the compound eyes of darkling beetles.Development genes and evolution · 2020Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- Article
- Evolution of Phototransduction Genes in Lepidoptera.Genome biology and evolution · 2019Article
- Development of functional ectopic compound eyes in scarabaeid beetles by knockdown ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Population Genomics ofGenetics · 2017Article
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
- Neofunctionalization of embryonic head patterning genes facilitates the positioning of novel traits on the dorsal head of adult beetles.Proceedings. Biological sciences · 2016Article
- Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation.Developmental biology · 2016Article
- Ancient default activators of terminal photoreceptor differentiation in the pancrustacean compound eye: the homeodomain transcription factors Otd and Pph13.Current opinion in insect science · 2016Review
- Single-base pair differences in a shared motif determine differential Rhodopsin expression.Science (New York, N.Y.) · 2015Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A hallmark of visual rhabdomeric photoreceptors is the expression of a rhabdomeric opsin and uniquely associated phototransduction molecules, which are incorporated into a specialized expanded apical membrane, the rhabdomere. Given the extensive utilization of rhabdomeric photoreceptors in the eyes of protostomes, here we address whether a common transcriptional mechanism exists for the differentiation of rhabdomeric photoreceptors. In Drosophila, the transcription factors Pph13 and Orthodenticle (Otd) direct both aspects of differentiation: rhabdomeric opsin transcription and rhabdomere morphogenesis. We demonstrate that the orthologs of both proteins are expressed in the visual systems of the distantly related arthropod species Tribolium castaneum and Daphnia magna and that their functional roles are similar in these species. In particular, we establish that the Pph13 homologs have the ability to bind a subset of Rhodopsin core sequence I sites and that these sites are present in key phototransduction genes of both Tribolium and Daphnia. Furthermore, Pph13 and Otd orthologs are capable of executing deeply conserved functions of photoreceptor differentiation as evidenced by the ability to rescue their respective Drosophila mutant phenotypes. Pph13 homologs are equivalent in their ability to direct both rhabdomere morphogenesis and opsin expression within Drosophila, whereas Otd paralogs demonstrate differential abilities to regulate photoreceptor differentiation. Finally, loss-of-function analyses in Tribolium confirm the conserved requirement of Pph13 and Otd in regulating both rhabdomeric opsin transcription and rhabdomere morphogenesis. Taken together, our data identify components of a regulatory framework for rhabdomeric photoreceptor differentiation in Pancrustaceans, providing a foundation for defining ancestral regulatory modules of rhabdomeric photoreceptor differentiation.
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